1996
GABA Levels in the Brain: A Target for New Antiepileptic Drugs
Kocsis J, Mattson R. GABA Levels in the Brain: A Target for New Antiepileptic Drugs. The Neuroscientist 1996, 2: 326-334. DOI: 10.1177/107385849600200610.Peer-Reviewed Original ResearchAntiepileptic drugsGABA levelsBrain GABA systemsBrain GABA levelsSeverity of seizuresNew antiepileptic drugsAbundant inhibitory neurotransmitterGABA receptor sitesNormal electrical activityMinimal side effectsPrecise cellular mechanismsAntiepileptic actionGABA releaseSeizure dischargesGABA systemPharmacological treatmentInhibitory neurotransmitterCNS neuronsEffective antiepilepticSide effectsElectrophysiological studiesMetabolic modulatorsClinical useSodium channelsDrugs
1986
Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine
Targ E, Kocsis J. Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine. Brain Research 1986, 363: 1-9. PMID: 3004637, DOI: 10.1016/0006-8993(86)90652-9.Peer-Reviewed Original ResearchConceptsAction potentialsSciatic nerveFrequency-following abilityMultiple spike dischargesSite of demyelinationCompound action potentialPotassium channel blockerRat sciatic nerveAction potential characteristicsVariety of abnormalitiesAbsolute refractory periodExcitability changesPharmacological blockadeSpontaneous firingDemyelinated axonsChannel blockersConduction slowingConduction blockSpike dischargesLesion siteRefractory periodExcitability propertiesClinical useAxonsPotassium channels