1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1988
Presynaptic actions of carbachol and adenosine on corticostriatal synaptic transmission studied in vitro
Malenka R, Kocsis J. Presynaptic actions of carbachol and adenosine on corticostriatal synaptic transmission studied in vitro. Journal Of Neuroscience 1988, 8: 3750-3756. PMID: 2848109, PMCID: PMC6569613, DOI: 10.1523/jneurosci.08-10-03750.1988.Peer-Reviewed Original ResearchConceptsStriatal neuronsSynaptic transmissionCorticostriatal synaptic transmissionExcitatory amino acidsField potentialsNeostriatal slice preparationField potential responsesCorticostriatal afferentsCorticostriatal responsesCorticostriatal fibersPresynaptic actionPostsynaptic actionsStriatal neurotransmittersCalcium antagonistsCarbachol actionCortical afferentsAfferent fibersIntrinsic neuronsStriatal afferentsPutative neurotransmittersAdenosine actionSlice preparationCorpus callosumNeostriatal slicesAfferentsBuspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability
Hiner B, Mauk M, Peroutka S, Kocsis J. Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain Research 1988, 461: 1-9. PMID: 2906267, DOI: 10.1016/0006-8993(88)90719-6.Peer-Reviewed Original ResearchConceptsCerebellar parallel fibersSerotonergic mechanismsNerve excitabilityFiber excitabilityAction potentialsSucrose gap recordingsEffects of serotoninNovel anxiolytic buspironeCompound action potentialDose-dependent reductionSchaffer collateral fibersParallel fibersAfferent fibersSciatic nerveReversible decrementsCollateral fibersAnxiolytic buspironeConduction velocityDPATIpsapironeGap recordingsBuspironeCerebellar neuronsAxonal responseExcitabilityBuspirone attenuates synaptic activation of hippocampal pyramidal cells
Mauk, Peroutka S, Kocsis J. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. Journal Of Neuroscience 1988, 8: 1-11. PMID: 3339401, PMCID: PMC6569355, DOI: 10.1523/jneurosci.08-01-00001.1988.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsPyramidal cellsStratum radiatumSynaptic activationAfferent fibersHippocampal CA1 pyramidal cellsInput resistanceStimulation of afferentsEffects of buspironeCA1 pyramidal cellsHippocampal pyramidal cellsPostsynaptic potentialsPresynaptic fibersConduction slowingFiber excitabilitySpike activityAnxiolytic agentsBuspironeRefractory periodRadiatumRapid hyperpolarizationReceptor sitesMeasurable effectExcitabilityMembrane potential
1981
Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium
Malenka R, Kocsis J, Ransom B, Waxman S. Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium. Science 1981, 214: 339-341. PMID: 7280695, DOI: 10.1126/science.7280695.Peer-Reviewed Original ResearchConceptsSynaptic field potentialsField potentialsParallel fiber stimulationExtracellular potassium concentrationRat cerebellar cortexParallel fibersAfferent fibersPostsynaptic elementsFiber excitabilityCerebellar cortexExtracellular potassiumFiber stimulationExcitabilityMarked increasePotassium concentrationStimulationMolecular layer