Stable Isotope Labelling Kinetics: Models and methods to evaluate APP production rates with Posiphen treatment in the DISCOVER clinical trial
Elbert D, Galasko D, Farlow M, Aslanyan V, Pa J, Lucey B, Honig L, Moghekar A, Bateman R, Momper J, Rissman R, Balasubramanian A, Maccecchini M, Feldman H, Group A. Stable Isotope Labelling Kinetics: Models and methods to evaluate APP production rates with Posiphen treatment in the DISCOVER clinical trial. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.077287.Peer-Reviewed Original ResearchAβ40 concentrationsBeta-amyloid precursor protein (APP) mRNAAmyloid precursor protein (APP) mRNASequential dose cohortsHigh-dose groupMild AD dementiaPrecursor protein mRNADose cohortsVenous cathetersStudy armsAD dementiaDose groupDrug exposureVenous bloodPosiphenAβ kineticsDay 22Therapeutic potentialPlaceboDecreased productionGroup differencesPatientsPharmacodynamicsFurther clarificationHours