Featured Publications
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Kanner A, Saporta A, Kim D, Barry J, Altalib H, Omotola H, Jette N, O'Brien T, Nadkarni S, Winawer M, Sperling M, French J, Abou-Khalil B, Alldredge B, Bebin M, Cascino G, Cole A, Cook M, Detyniecki K, Devinsky O, Dlugos D, Faught E, Ficker D, Fields M, Gidal B, Gelfand M, Glynn S, Halford J, Haut S, Hegde M, Holmes M, Kalviainen R, Kang J, Klein P, Knowlton R, Krishnamurthy K, Kuzniecky R, Kwan P, Lowenstein D, Marcuse L, Meador K, Mintzer S, Pardoe H, Park K, Penovich P, Singh R, Somerville E, Szabo C, Szaflarski J, Thio K, Trinka E, Burneo J, Project A. Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy. Neurology 2022, 100: e1123-e1134. PMID: 36539302, PMCID: PMC10074468, DOI: 10.1212/wnl.0000000000201671.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFocal epilepsyBipolar disorderSuicidal ideationAnxiety disordersGeneral populationSuicidal attemptsPanic disorderMini International Neuropsychiatric InterviewPrevalence of moodInternational Neuropsychiatric InterviewLogistic regression analysisActive suicidal ideationComparable prevalence ratesSeverity Rating ScaleConsecutive adultsDepressive disorderNeuropsychiatric InterviewEpilepsy evaluationHigh prevalencePrevalence ratesTypes of moodPatientsPsychiatric diagnosisEpilepsyDorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients
Dhaher R, Bronen RA, Spencer L, Colic L, Brown F, Mian A, Sandhu M, Pittman B, Spencer D, Blumberg HP, Altalib H. Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients. Epilepsia 2022, 63: 2561-2570. PMID: 35883245, DOI: 10.1111/epi.17377.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyDorsal bed nucleusTLE patientsEpilepsy patientsBed nucleusHC subjectsStria terminalisTemporal lobe epilepsy patientsMini International Neuropsychiatric InterviewMagnetic resonance imaging (MRI) scansTreatment-resistant depressionComprehensive Epilepsy CenterHealthy control subjectsStructural magnetic resonance imaging (MRI) scansResonance imaging scansNumber of patientsCase-control studyInternational Neuropsychiatric InterviewMajor depressive disorderCommon comorbid disordersHuman clinical studiesEpilepsy centersLobe epilepsyComorbid depressionControl subjectsSuicide Attempts of Muslims Compared With Other Religious Groups in the US
Awaad R, El-Gabalawy O, Jackson-Shaheed E, Zia B, Keshavarzi H, Mogahed D, Altalib H. Suicide Attempts of Muslims Compared With Other Religious Groups in the US. JAMA Psychiatry 2021, 78: 1041-1044. PMID: 34287614, PMCID: PMC8295887, DOI: 10.1001/jamapsychiatry.2021.1813.Peer-Reviewed Original ResearchEpilepsy quality performance in a national sample of neurologists and primary care providers: Characterizing trends in acute and chronic care management
Altalib H, McMillan KK, Padilla S, Pugh MJ. Epilepsy quality performance in a national sample of neurologists and primary care providers: Characterizing trends in acute and chronic care management. Epilepsy & Behavior 2021, 123: 108218. PMID: 34479039, DOI: 10.1016/j.yebeh.2021.108218.Peer-Reviewed Original ResearchConceptsPrimary care providersEpilepsy carePrimary careChronic careInjury preventionCare providersPsychosocial educationVeterans Affairs Healthcare SystemAnti-seizure medicationsMedication side effectsNew-onset seizuresTypes of seizuresChronic care managementHealthcare systemProportion of peopleChart reviewChart extractionAcute careMedication monotherapyNational sampleTreatment optionsSpecialty careCare measuresVA measurementsSide effectsMeasuring coordination of epilepsy care: A mixed methods evaluation of social network analysis versus relational coordination
Altalib HH, Lanham HJ, McMillan KK, Habeeb M, Fenton B, Cheung KH, Pugh MJ. Measuring coordination of epilepsy care: A mixed methods evaluation of social network analysis versus relational coordination. Epilepsy & Behavior 2019, 97: 197-205. PMID: 31252279, DOI: 10.1016/j.yebeh.2019.05.023.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health Care, IntegratedEpilepsyHealth PersonnelHealth ServicesHospitals, VeteransHumansModels, OrganizationalNeurologistsPatient Care TeamReferral and ConsultationSocial NetworkingSocial SupportSurveys and QuestionnairesUnited StatesUnited States Department of Veterans AffairsConceptsCoordination of careVeterans Affairs Healthcare SystemVA providersEpilepsy careNeurological careHealthcare systemHealthcare teamPrimary care providersModel of careCare team membersLarge healthcare systemVA healthcare systemMental health providersHealth professional networksRelational coordinationMixed-methods evaluationKey informant interviewsMultidisciplinary careEpilepsy centersNeurology settingCare scoresProvider teamCare mapCare providersVA facilities
2024
Cognitive performance in functional seizures compared with epilepsy and healthy controls: a systematic review and meta analysis
Van Patten R, Austin T, Cotton E, Chan L, Bellone J, Mordecai K, Altalib H, Correia S, Twamley E, Jones R, Sawyer K, LaFrance W. Cognitive performance in functional seizures compared with epilepsy and healthy controls: a systematic review and meta analysis. The Lancet Psychiatry 2024, 11: 516-525. PMID: 38879275, DOI: 10.1016/s2215-0366(24)00132-9.Peer-Reviewed Original ResearchConceptsRisk of biasSystematic reviewHealthy comparisonGlobal cognitionMeta-analysisCognitive performanceDepartment of Veterans AffairsVeterans Health AdministrationFunctional seizuresIndividual studiesCognitive domainsModerate effect sizeProportion of womenNewcastle-Ottawa ScaleLeft temporal lobe epilepsyWeb of ScienceCognitive test dataWidespread cognitive impairmentVeterans AffairsEffects of multiple covariatesHealth AdministrationGrey literatureSeizure groupNewcastle-OttawaInclusion criteria
2023
Role of Deployment History on the Association Between Epilepsy and Traumatic Brain Injury in Post–9/11 Era US Veterans
Henion A, Wang C, Amuan M, Altalib H, Towne A, Hinds S, Baca C, LaFrance W, Van Cott A, Kean J, Roghani A, Kennedy E, Panahi S, Pugh M. Role of Deployment History on the Association Between Epilepsy and Traumatic Brain Injury in Post–9/11 Era US Veterans. Neurology 2023, 101: e2571-e2584. PMID: 38030395, PMCID: PMC10791059, DOI: 10.1212/wnl.0000000000207943.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDeployed veteransNondeployed veteransHigher oddsNeurologic conditionsBrain injuryEpilepsy impactDeployment-related traumatic brain injurySevere traumatic brain injuryEpilepsy risk factorsMild traumatic brain injuryVeterans Health AdministrationYears of careDeployment-related exposuresService membersService-connected disabilityHistory of deploymentHealthy warrior effectLogistic regression modelsDeployment historyMilitary service membersEpilepsy preventionICD-9/10TBI exposureAntiseizure medicationsImplementer report: ICD-10 code F44.5 review for functional seizure disorder
Ali S, Bornovski Y, Gopaul M, Galluzzo D, Goulet J, Argraves S, Jackson-Shaheed E, Cheung K, Brandt C, Altalib H. Implementer report: ICD-10 code F44.5 review for functional seizure disorder. BMJ Health & Care Informatics 2023, 30: e100746. PMID: 37730251, PMCID: PMC10514602, DOI: 10.1136/bmjhci-2023-100746.Peer-Reviewed Original ResearchConceptsPositive predictive valueSeizure disorderICD-10Single ICD codeEHR problem listElectronic health recordsChart reviewDiagnostic codesInternational ClassificationDiagnostic codingPredictive valueICD codesProblem listDiagnostic precisionHealth recordsDisordersNatural language processing algorithmEHR systemsLanguage processing algorithmReviewCliniciansDiseaseUnderstanding headache classification coding within the veterans health administration using ICD-9-CM and ICD-10-CM in fiscal years 2014–2017
Fodeh S, Fenton B, Wang R, Skanderson M, Altalib H, Kuruvilla D, Schindler E, Haskell S, Brandt C, Sico J. Understanding headache classification coding within the veterans health administration using ICD-9-CM and ICD-10-CM in fiscal years 2014–2017. PLOS ONE 2023, 18: e0279163. PMID: 36598881, PMCID: PMC9812322, DOI: 10.1371/journal.pone.0279163.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHeadache diagnosisICD-10-CMICD-10-CM diagnosisICD-10-CM codingSpecialty care clinicsSpecific headache diagnosesICD-9-CM codingDifferent headache typesICD-9-CMRace/ethnicityHeadache comorbidityHeadache NOSPatient ageCare clinicsChronic conditionsHeadache typesProvider typeSociodemographic factorsHealth AdministrationDiagnosisTwo yearsHeadachePatientsMigraine
2021
The Military Injuries: Understanding Post-Traumatic Epilepsy Study: Understanding Relationships among Lifetime Traumatic Brain Injury History, Epilepsy, and Quality of Life
Pugh MJ, Kennedy E, Gugger JJ, Mayo J, Tate D, Swan A, Kean J, Altalib H, Gowda S, Towne A, Hinds S, Van Cott A, Lopez MR, Jaramillo CA, Eapen BC, McCafferty RR, Salinsky M, Cramer J, McMillan KK, Kalvesmaki A, Diaz-Arrastia R, Amuan M, Henion A, Padilla S, McCafferty M, Elizondo B, Wells M. The Military Injuries: Understanding Post-Traumatic Epilepsy Study: Understanding Relationships among Lifetime Traumatic Brain Injury History, Epilepsy, and Quality of Life. Journal Of Neurotrauma 2021, 38: 2841-2850. PMID: 34353118, PMCID: PMC8820288, DOI: 10.1089/neu.2021.0015.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryPost-traumatic epilepsyHistory of TBIQuality of lifeEvidence of TBILifetime traumatic brain injuryMild traumatic brain injuryHealth recordsHealth-related qualityVA medical recordsWorse physical functioningPopulation-based assessmentVeterans Health AdministrationHealth record dataTraumatic brain injury historyBrain injury historyComplex comorbiditiesMedical recordsBrain injuryPhysical functioningTBI severityInjury historyEpilepsyHealth AdministrationEpilepsy studies
2017
Care coordination in epilepsy: Measuring neurologists' connectivity using social network analysis
Altalib HH, Fenton BT, Cheung KH, Pugh MJV, Bates J, Valente TW, Kerns RD, Brandt CA. Care coordination in epilepsy: Measuring neurologists' connectivity using social network analysis. Epilepsy & Behavior 2017, 73: 31-35. PMID: 28605631, DOI: 10.1016/j.yebeh.2017.05.026.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationCare coordinationHealth care providersCare providersVA facilitiesEpilepsy centersSpecialty careEpilepsy careEpilepsy patientsHealth AdministrationFacility levelNumber of providersNeurologistsFacility typeCareProvidersType of facilityMixed modelsSame facilityPatientsEpilepsyAdministration
2016
Incidence of Mental Health Diagnoses in Veterans of Operations Iraqi Freedom, Enduring Freedom, and New Dawn, 2001-2014.
Ramsey C, Dziura J, Justice AC, Altalib HH, Bathulapalli H, Burg M, Decker S, Driscoll M, Goulet J, Haskell S, Kulas J, Wang KH, Mattocks K, Brandt C. Incidence of Mental Health Diagnoses in Veterans of Operations Iraqi Freedom, Enduring Freedom, and New Dawn, 2001-2014. American Journal Of Public Health 2016, 107: 329-335. PMID: 27997229, PMCID: PMC5227942, DOI: 10.2105/ajph.2016.303574.Peer-Reviewed Original ResearchConceptsMental health diagnosesMajor depressive disorderPosttraumatic stress disorderHealth diagnosisIncidence rateDrug use disorder diagnosisIncident posttraumatic stress disorderOperation Iraqi FreedomAge 18Veterans Health Administration electronic health recordsDisorder diagnosisIncident bipolar disorderHigh-risk groupSociodemographic risk factorsAlcohol use disorder diagnosisMental health conditionsEnduring FreedomIraqi FreedomRace/ethnicityElectronic health recordsIncident schizophreniaRisk factorsDepressive disorderAge 45MDD diagnosisCommunicating diagnostic certainty of psychogenic nonepileptic seizures — a national study of provider documentation
Altalib HH, Elzamzamy K, Pugh MJ, Gonzalez JB, Cheung KH, Fenton BT, Kerns RD, Brandt CA, LaFrance WC. Communicating diagnostic certainty of psychogenic nonepileptic seizures — a national study of provider documentation. Epilepsy & Behavior 2016, 64: 4-8. PMID: 27723497, DOI: 10.1016/j.yebeh.2016.08.032.Peer-Reviewed Original ResearchConceptsPsychogenic nonepileptic seizuresElectronic health recordsNonepileptic seizuresVeterans Affairs electronic health recordsDiagnosis of PNESInappropriate health careMajority of patientsPrimary care providersImpressions of patientsHealth care professionalsMental health professionalsEpilepsy criteriaProvider documentationClinical impressionCare providersCare professionalsInternational LeagueDiagnostic certaintyHealth professionalsPatientsProgress notesHealth recordsHealth careSeizuresNeurologistsIncrease in migraine diagnoses and guideline-concordant treatment in veterans, 2004–2012
Altalib H, Fenton B, Sico J, Goulet J, Bathulapalli H, Mohammad A, Kulas J, Driscoll M, Dziura J, Mattocks K, Kerns R, Brandt C, Haskell S. Increase in migraine diagnoses and guideline-concordant treatment in veterans, 2004–2012. Cephalalgia 2016, 37: 3-10. PMID: 26950804, DOI: 10.1177/0333102416631959.Peer-Reviewed Original ResearchConceptsBurden of migraineMigraine diagnosisVeterans Health Administration electronic health recordsGuideline-concordant treatmentGuideline-concordant careMigraine-specific medicationsICD-9 codesChi-square testHealth care systemNumber of veteransElectronic health recordsTriptan prescriptionMigraine preventionGuideline adherenceMigraine medicationsComorbid conditionsNational health care systemMigraine headacheMedicationsMigraineTime-series studyLogistic regressionCare systemPreventive medicineHealth administrators
2014
Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery
Hamid H, Blackmon K, Cong X, Dziura J, Atlas LY, Vickrey BG, Berg AT, Bazil CW, Langfitt JT, Walczak TS, Sperling MR, Shinnar S, Devinsky O. Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. Neurology 2014, 82: 887-894. PMID: 24489129, PMCID: PMC3959755, DOI: 10.1212/wnl.0000000000000183.Peer-Reviewed Original ResearchConceptsBeck Depression InventorySeizure controlOverall QOL scoreEpilepsy surgeryQuality of lifeBeck Anxiety InventoryQOL scoresOverall QoLBAI scoresMixed-model repeated-measures analysisPartial seizure controlGood seizure controlPoor seizure controlAssociation of depressionComprehensive diagnostic workupEpilepsy Inventory-89Incomplete seizure controlManagement of moodRepeated-measures analysisQoL subscoresSeizure outcomeEpilepsy centersWorse QoLDiagnostic workupPostsurgical care
2013
Validating a natural language processing tool to exclude psychogenic nonepileptic seizures in electronic medical record-based epilepsy research
Hamid H, Fodeh SJ, Lizama AG, Czlapinski R, Pugh MJ, LaFrance WC, Brandt CA. Validating a natural language processing tool to exclude psychogenic nonepileptic seizures in electronic medical record-based epilepsy research. Epilepsy & Behavior 2013, 29: 578-580. PMID: 24135384, DOI: 10.1016/j.yebeh.2013.09.025.Peer-Reviewed Original ResearchConceptsPsychogenic nonepileptic seizuresPositive predictive valueNonepileptic seizuresDefinite PNESAfghanistan veteransEpilepsy researchNational Clinical DatabaseVideo electroencephalograph monitoringDiagnosis of epilepsySeizure disorderDefinitive diagnosisElectronic health record systemsEpidemiologic dataHealth record systemsPredictive valueClinical databaseElectroencephalograph monitoringPatientsEpilepsyVEEGEpidemiologic researchVeteransRecord systemSeizuresDiagnosis
2011
Long-term association between seizure outcome and depression after resective epilepsy surgery
Hamid H, Liu H, Cong X, Devinsky O, Berg AT, Vickrey BG, Sperling MR, Shinnar S, Langfitt JT, Walczak TS, Barr WB, Dziura J, Bazil CW, Spencer SS. Long-term association between seizure outcome and depression after resective epilepsy surgery. Neurology 2011, 77: 1972-1976. PMID: 22094480, PMCID: PMC3235357, DOI: 10.1212/wnl.0b013e31823a0c90.Peer-Reviewed Original ResearchConceptsSeizure control groupExcellent seizure controlResective epilepsy surgerySeizure controlBeck Depression InventoryDepressive symptomsControl groupEpilepsy surgeryBDI scoresMixed-model repeated-measures analysisBorderline significant reductionEpilepsy surgery outcomeGood seizure controlMulticenter prospective studyLong-term improvementRepeated-measures analysisSeizure outcomeResective surgeryProspective studySurgery outcomesSevere depressionMean changeInitial improvementSurgeryCase status
2010
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresSlow wave activityTemporal lobe epilepsySimple partial seizuresSubcortical arousal systemsImpaired consciousnessSeizure activityTemporal lobeLobe epilepsyArousal systemCortical functionFocal temporal lobe seizuresHz slow wave activityMesial temporal lobe epilepsyCortical slow activityDepressed cortical functionNetwork inhibition hypothesisTemporal lobe disordersComplex partial seizuresBilateral temporal lobesLanguage-dominant temporal lobeSlow wavesCortical-subcortical networksPowerful inhibitory effectIntracranial electroencephalography recordingsA prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games
Yang L, Morland TB, Schmits K, Rawson E, Narasimhan P, Motelow JE, Purcaro MJ, Peng K, Raouf S, DeSalvo MN, Oh T, Wilkerson J, Bod J, Srinivasan A, Kurashvili P, Anaya J, Manza P, Danielson N, Ransom CB, Huh L, Elrich S, Padin-Rosado J, Naidu Y, Detyniecki K, Hamid H, Farooque P, Astur R, Xiao B, Duckrow RB, Blumenfeld H. A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games. Epilepsy & Behavior 2010, 18: 238-246. PMID: 20537593, PMCID: PMC2914099, DOI: 10.1016/j.yebeh.2010.04.011.Peer-Reviewed Original ResearchConceptsVideo gamesVirtual realityComputer-based tasksDaily lifePerformance dataProspective studyEssential partGameContinuous video/EEG monitoringVideo/EEG monitoringTraffic accidentsSimulatorNetworkTaskNormal daily lifeSeizure typesDrivingEEG monitoringSeizuresDriving impairmentPatientsImpair consciousnessSpecific typesAnatomical networksReality