Featured Publications
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Kanner A, Saporta A, Kim D, Barry J, Altalib H, Omotola H, Jette N, O'Brien T, Nadkarni S, Winawer M, Sperling M, French J, Abou-Khalil B, Alldredge B, Bebin M, Cascino G, Cole A, Cook M, Detyniecki K, Devinsky O, Dlugos D, Faught E, Ficker D, Fields M, Gidal B, Gelfand M, Glynn S, Halford J, Haut S, Hegde M, Holmes M, Kalviainen R, Kang J, Klein P, Knowlton R, Krishnamurthy K, Kuzniecky R, Kwan P, Lowenstein D, Marcuse L, Meador K, Mintzer S, Pardoe H, Park K, Penovich P, Singh R, Somerville E, Szabo C, Szaflarski J, Thio K, Trinka E, Burneo J, Project A. Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy. Neurology 2022, 100: e1123-e1134. PMID: 36539302, PMCID: PMC10074468, DOI: 10.1212/wnl.0000000000201671.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFocal epilepsyBipolar disorderSuicidal ideationAnxiety disordersGeneral populationSuicidal attemptsPanic disorderMini International Neuropsychiatric InterviewPrevalence of moodInternational Neuropsychiatric InterviewLogistic regression analysisActive suicidal ideationComparable prevalence ratesSeverity Rating ScaleConsecutive adultsDepressive disorderNeuropsychiatric InterviewEpilepsy evaluationHigh prevalencePrevalence ratesTypes of moodPatientsPsychiatric diagnosisEpilepsySuicide Attempts of Muslims Compared With Other Religious Groups in the US
Awaad R, El-Gabalawy O, Jackson-Shaheed E, Zia B, Keshavarzi H, Mogahed D, Altalib H. Suicide Attempts of Muslims Compared With Other Religious Groups in the US. JAMA Psychiatry 2021, 78: 1041-1044. PMID: 34287614, PMCID: PMC8295887, DOI: 10.1001/jamapsychiatry.2021.1813.Peer-Reviewed Original Research
2024
Cognitive performance in functional seizures compared with epilepsy and healthy controls: a systematic review and meta analysis
Van Patten R, Austin T, Cotton E, Chan L, Bellone J, Mordecai K, Altalib H, Correia S, Twamley E, Jones R, Sawyer K, LaFrance W. Cognitive performance in functional seizures compared with epilepsy and healthy controls: a systematic review and meta analysis. The Lancet Psychiatry 2024, 11: 516-525. PMID: 38879275, DOI: 10.1016/s2215-0366(24)00132-9.Peer-Reviewed Original ResearchConceptsRisk of biasSystematic reviewHealthy comparisonGlobal cognitionMeta-analysisCognitive performanceDepartment of Veterans AffairsVeterans Health AdministrationFunctional seizuresIndividual studiesCognitive domainsModerate effect sizeProportion of womenNewcastle-Ottawa ScaleLeft temporal lobe epilepsyWeb of ScienceCognitive test dataWidespread cognitive impairmentVeterans AffairsEffects of multiple covariatesHealth AdministrationGrey literatureSeizure groupNewcastle-OttawaInclusion criteria
2021
The Military Injuries: Understanding Post-Traumatic Epilepsy Study: Understanding Relationships among Lifetime Traumatic Brain Injury History, Epilepsy, and Quality of Life
Pugh MJ, Kennedy E, Gugger JJ, Mayo J, Tate D, Swan A, Kean J, Altalib H, Gowda S, Towne A, Hinds S, Van Cott A, Lopez MR, Jaramillo CA, Eapen BC, McCafferty RR, Salinsky M, Cramer J, McMillan KK, Kalvesmaki A, Diaz-Arrastia R, Amuan M, Henion A, Padilla S, McCafferty M, Elizondo B, Wells M. The Military Injuries: Understanding Post-Traumatic Epilepsy Study: Understanding Relationships among Lifetime Traumatic Brain Injury History, Epilepsy, and Quality of Life. Journal Of Neurotrauma 2021, 38: 2841-2850. PMID: 34353118, PMCID: PMC8820288, DOI: 10.1089/neu.2021.0015.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryPost-traumatic epilepsyHistory of TBIQuality of lifeEvidence of TBILifetime traumatic brain injuryMild traumatic brain injuryHealth recordsHealth-related qualityVA medical recordsWorse physical functioningPopulation-based assessmentVeterans Health AdministrationHealth record dataTraumatic brain injury historyBrain injury historyComplex comorbiditiesMedical recordsBrain injuryPhysical functioningTBI severityInjury historyEpilepsyHealth AdministrationEpilepsy studies
2016
Incidence of Mental Health Diagnoses in Veterans of Operations Iraqi Freedom, Enduring Freedom, and New Dawn, 2001-2014.
Ramsey C, Dziura J, Justice AC, Altalib HH, Bathulapalli H, Burg M, Decker S, Driscoll M, Goulet J, Haskell S, Kulas J, Wang KH, Mattocks K, Brandt C. Incidence of Mental Health Diagnoses in Veterans of Operations Iraqi Freedom, Enduring Freedom, and New Dawn, 2001-2014. American Journal Of Public Health 2016, 107: 329-335. PMID: 27997229, PMCID: PMC5227942, DOI: 10.2105/ajph.2016.303574.Peer-Reviewed Original ResearchConceptsMental health diagnosesMajor depressive disorderPosttraumatic stress disorderHealth diagnosisIncidence rateDrug use disorder diagnosisIncident posttraumatic stress disorderOperation Iraqi FreedomAge 18Veterans Health Administration electronic health recordsDisorder diagnosisIncident bipolar disorderHigh-risk groupSociodemographic risk factorsAlcohol use disorder diagnosisMental health conditionsEnduring FreedomIraqi FreedomRace/ethnicityElectronic health recordsIncident schizophreniaRisk factorsDepressive disorderAge 45MDD diagnosisIncrease in migraine diagnoses and guideline-concordant treatment in veterans, 2004–2012
Altalib H, Fenton B, Sico J, Goulet J, Bathulapalli H, Mohammad A, Kulas J, Driscoll M, Dziura J, Mattocks K, Kerns R, Brandt C, Haskell S. Increase in migraine diagnoses and guideline-concordant treatment in veterans, 2004–2012. Cephalalgia 2016, 37: 3-10. PMID: 26950804, DOI: 10.1177/0333102416631959.Peer-Reviewed Original ResearchConceptsBurden of migraineMigraine diagnosisVeterans Health Administration electronic health recordsGuideline-concordant treatmentGuideline-concordant careMigraine-specific medicationsICD-9 codesChi-square testHealth care systemNumber of veteransElectronic health recordsTriptan prescriptionMigraine preventionGuideline adherenceMigraine medicationsComorbid conditionsNational health care systemMigraine headacheMedicationsMigraineTime-series studyLogistic regressionCare systemPreventive medicineHealth administrators
2014
Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery
Hamid H, Blackmon K, Cong X, Dziura J, Atlas LY, Vickrey BG, Berg AT, Bazil CW, Langfitt JT, Walczak TS, Sperling MR, Shinnar S, Devinsky O. Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. Neurology 2014, 82: 887-894. PMID: 24489129, PMCID: PMC3959755, DOI: 10.1212/wnl.0000000000000183.Peer-Reviewed Original ResearchConceptsBeck Depression InventorySeizure controlOverall QOL scoreEpilepsy surgeryQuality of lifeBeck Anxiety InventoryQOL scoresOverall QoLBAI scoresMixed-model repeated-measures analysisPartial seizure controlGood seizure controlPoor seizure controlAssociation of depressionComprehensive diagnostic workupEpilepsy Inventory-89Incomplete seizure controlManagement of moodRepeated-measures analysisQoL subscoresSeizure outcomeEpilepsy centersWorse QoLDiagnostic workupPostsurgical care
2011
Long-term association between seizure outcome and depression after resective epilepsy surgery
Hamid H, Liu H, Cong X, Devinsky O, Berg AT, Vickrey BG, Sperling MR, Shinnar S, Langfitt JT, Walczak TS, Barr WB, Dziura J, Bazil CW, Spencer SS. Long-term association between seizure outcome and depression after resective epilepsy surgery. Neurology 2011, 77: 1972-1976. PMID: 22094480, PMCID: PMC3235357, DOI: 10.1212/wnl.0b013e31823a0c90.Peer-Reviewed Original ResearchConceptsSeizure control groupExcellent seizure controlResective epilepsy surgerySeizure controlBeck Depression InventoryDepressive symptomsControl groupEpilepsy surgeryBDI scoresMixed-model repeated-measures analysisBorderline significant reductionEpilepsy surgery outcomeGood seizure controlMulticenter prospective studyLong-term improvementRepeated-measures analysisSeizure outcomeResective surgeryProspective studySurgery outcomesSevere depressionMean changeInitial improvementSurgeryCase status
2010
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresSlow wave activityTemporal lobe epilepsySimple partial seizuresSubcortical arousal systemsImpaired consciousnessSeizure activityTemporal lobeLobe epilepsyArousal systemCortical functionFocal temporal lobe seizuresHz slow wave activityMesial temporal lobe epilepsyCortical slow activityDepressed cortical functionNetwork inhibition hypothesisTemporal lobe disordersComplex partial seizuresBilateral temporal lobesLanguage-dominant temporal lobeSlow wavesCortical-subcortical networksPowerful inhibitory effectIntracranial electroencephalography recordingsA prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games
Yang L, Morland TB, Schmits K, Rawson E, Narasimhan P, Motelow JE, Purcaro MJ, Peng K, Raouf S, DeSalvo MN, Oh T, Wilkerson J, Bod J, Srinivasan A, Kurashvili P, Anaya J, Manza P, Danielson N, Ransom CB, Huh L, Elrich S, Padin-Rosado J, Naidu Y, Detyniecki K, Hamid H, Farooque P, Astur R, Xiao B, Duckrow RB, Blumenfeld H. A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games. Epilepsy & Behavior 2010, 18: 238-246. PMID: 20537593, PMCID: PMC2914099, DOI: 10.1016/j.yebeh.2010.04.011.Peer-Reviewed Original ResearchConceptsVideo gamesVirtual realityComputer-based tasksDaily lifePerformance dataProspective studyEssential partGameContinuous video/EEG monitoringVideo/EEG monitoringTraffic accidentsSimulatorNetworkTaskNormal daily lifeSeizure typesDrivingEEG monitoringSeizuresDriving impairmentPatientsImpair consciousnessSpecific typesAnatomical networksReality