2000
Brain‐Derived Neurotrophic Factor Induces Excitotoxic Sensitivity in Cultured Embryonic Rat Spinal Motor Neurons Through Activation of the Phosphatidylinositol 3‐Kinase Pathway
Fryer H, Wolf D, Knox R, Strittmatter S, Pennica D, O'Leary R, Russell D, Kalb R. Brain‐Derived Neurotrophic Factor Induces Excitotoxic Sensitivity in Cultured Embryonic Rat Spinal Motor Neurons Through Activation of the Phosphatidylinositol 3‐Kinase Pathway. Journal Of Neurochemistry 2000, 74: 582-595. PMID: 10646509, DOI: 10.1046/j.1471-4159.2000.740582.x.Peer-Reviewed Original ResearchConceptsHerpes simplex virusBrain-derived neurotrophic factorNeurotrophic factorMotor neuronsGlial-derived neurotrophic factorRat spinal motor neuronsEffects of BDNFRat motor neuronsSpinal motor neuronsActivation of TrkBPI3K pathwayExcitotoxic deathNeurotrophin-3Receptor p75NTRBDNFSimplex virusIntracellular Ca2Cardiotrophin-1NeuronsReceptor-mediated cell deathK pathwayPI3KDominant negative p85 subunitTrkBCell death
1998
Differential Regulation of Neurotrophin and trkReceptor mRNAs in Catecholaminergic Nuclei during Chronic Opiate Treatment and Withdrawal
Numan S, Lane-Ladd S, Zhang L, Lundgren K, Russell D, Seroogy K, Nestler E. Differential Regulation of Neurotrophin and trkReceptor mRNAs in Catecholaminergic Nuclei during Chronic Opiate Treatment and Withdrawal. Journal Of Neuroscience 1998, 18: 10700-10708. PMID: 9852605, PMCID: PMC6793370, DOI: 10.1523/jneurosci.18-24-10700.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorDrug Administration ScheduleDrug ImplantsGene Expression RegulationLocus CoeruleusMaleMesencephalonMorphineNerve Growth FactorsNeurotrophin 3RatsRats, Sprague-DawleyReceptor Protein-Tyrosine KinasesReceptor, Ciliary Neurotrophic FactorReceptor, trkCReceptors, Nerve Growth FactorRNA, MessengerTime FactorsVentral Tegmental AreaConceptsBrain-derived neurotrophic factorVentral tegmental areaChronic morphine treatmentChronic opiate treatmentLocus coeruleusHr of withdrawalMorphine treatmentNeurotrophin-3TrkC mRNAOpiate treatmentNeurotrophin brain-derived neurotrophic factorNT-3 mRNA expressionLevels of TrkBOpiate-induced plasticityTrkB mRNA levelsChronic morphine exposureNT-3 mRNATrkC mRNA levelsMRNA levelsEndogenous neurotrophinsExogenous neurotrophinsTrk mRNABDNF mRNAMorphine exposureTrkB mRNA
1995
Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system
Berhow M, Russell D, Terwilliger R, Beitner-Johnson D, Self D, Lindsay R, Nestler E. Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 1995, 68: 969-979. PMID: 8545003, DOI: 10.1016/0306-4522(95)00207-y.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdenylyl CyclasesAnimalsAutoradiographyCocaineCyclic AMP-Dependent Protein KinasesDopamineGlial Fibrillary Acidic ProteinInjectionsLimbic SystemMaleMorphineNarcotic AntagonistsNarcoticsNerve Growth FactorsNeurofilament ProteinsNucleus AccumbensRatsRats, Sprague-DawleyTyrosine 3-MonooxygenaseVentral Tegmental AreaConceptsVentral tegmental areaIntra-ventral tegmental area infusionBrain-derived neurotrophic factorGlial fibrillary acidic proteinTyrosine hydroxylase levelsNeurotrophic factorFactor infusionFibrillary acidic proteinTegmental areaMorphine treatmentNerve growth factorAdenylyl cyclase activityNucleus accumbensTyrosine hydroxylaseChronic morphineNeurotrophin-4Cocaine treatmentCocaine exposureHydroxylase levelsGlial fibrillary acidic protein levelsAcidic proteinCyclase activityGrowth factorChronic morphine treatmentChronic cocaine treatment