2001
Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
Werner P, Pitt D, Raine C. Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Annals Of Neurology 2001, 50: 169-180. PMID: 11506399, DOI: 10.1002/ana.1077.Peer-Reviewed Original ResearchConceptsMultiple sclerosisAxonal damageWhite matterGlutamate excitotoxicityGlutamate homeostasisMS lesionsGlutaminase expressionMS white matterInflammatory neurologic diseasesActive MS lesionsCNS cell typesOligodendroglial pathologyNoninflammatory conditionsDystrophic axonsNeurologic diseaseGLT-1Low-level expressionAnimal modelsGlutamate transportersHomeostasis contributesLesion correlatesGlutamate transportLesionsOligodendrocytesTherapeutic import
1999
Neuregulin and erbB receptor expression in normal and diseased human white matter
Cannella B, Pitt D, Marchionni M, Raine C. Neuregulin and erbB receptor expression in normal and diseased human white matter. Journal Of Neuroimmunology 1999, 100: 233-242. PMID: 10695733, DOI: 10.1016/s0165-5728(99)00201-5.Peer-Reviewed Original ResearchConceptsGlial growth factor 2Multiple sclerosisErbB receptor expressionWhite matterHuman white matterReceptor expressionCases of MSHuman lymph node tissueAreas of remyelinationLymph node tissueGrowth factor 2Autoimmune demyelinationMicroglial cellsNeurologic diseaseMS lesionsNode tissueMitogenic effectWestern blotWestern blottingOligodendrocytesReceptorsRemyelinationWidespread expressionFactor 2Lymphocytes