2012
Prostaglandin E2 affects T cell responses through modulation of CD46 expression. (178.8)
Astier A, Kickler K, Ni Choileain S, Stephen J, Hafler D, Jabbour H. Prostaglandin E2 affects T cell responses through modulation of CD46 expression. (178.8). The Journal Of Immunology 2012, 188: 178.8-178.8. DOI: 10.4049/jimmunol.188.supp.178.8.Peer-Reviewed Original ResearchT cell functionCell functionReceptor kinase familyT cell activationProstaglandin E2CD46 expressionT cellsPrimary T cellsKinase familyCytokine productionCD46 functionsCell activationRegulatory mechanismsDiverse rolesDifferentiation pathwayNovel roleG proteinsCell surfaceRole of PGE2Addition of PGE2T cell surfaceT cell responsesChronic inflammatory diseaseComplement regulator CD46Activation signals
2009
Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells
Costantino CM, Ploegh HL, Hafler DA. Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells. The Journal Of Immunology 2009, 183: 945-952. PMID: 19553543, PMCID: PMC2752291, DOI: 10.4049/jimmunol.0900921.Peer-Reviewed Original ResearchConceptsT cellsCathepsin S expressionSelf-Ag presentationClass II MHC moleculesClass II MHCT cell clonesCathepsin SII MHC moleculesCLIP expressionProfessional APCsConsequence of activationII MHCHuman CD4Presentation pathwayB cellsMHC moleculesEx vivoHLACell clonesInvariant chain proteolysisLysosomal proteasesS expressionCellsActivationCell surface
1987
Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones.
Ang SL, Seidman JG, Peterman GM, Duby AD, Benjamin D, Lee SJ, Hafler DA. Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones. Journal Of Experimental Medicine 1987, 165: 1453-1458. PMID: 3106557, PMCID: PMC2188318, DOI: 10.1084/jem.165.5.1453.Peer-Reviewed Original ResearchConceptsAnti-CD3 mAbT cell clonesCerebrospinal fluidCell clonesIndependent T cell clonesNK-like activityHuman immune responseT cell receptorWT-31IL-2T cellsImmune responseIntracellular calciumCell receptorMAbsTcR gamma proteinGamma proteinSepharose beadsCell surfacePhenotypic analysisCD8CD4PanencephalitisSubacutePatients