2020
Post-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone
Atif F, Yousuf S, Espinosa-Garcia C, Harris W, Stein D. Post-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone. Neuropharmacology 2020, 181: 108327. PMID: 32950558, DOI: 10.1016/j.neuropharm.2020.108327.Peer-Reviewed Original ResearchConceptsPeripheral immune dysfunctionVitamin D hormoneTransient middle cerebral artery occlusion/reperfusionImmune dysfunctionSystemic inflammationInfarct volumeSubsets of immune cellsNeuronal inflammationMeasure infarct volumePost-stroke infectionsInjection of lipopolysaccharideIn-hospital infectionStandard of careFlow cytometric analysisMiddle cerebral artery occlusion/reperfusionCleaved caspase-3Combination therapyInflammation groupImmune cellsAdult ratsIncreased morbidityD hormoneBrain post-strokeImmunomodulatory effectsCombined treatment
2019
Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma
Atif F, Yousuf S, Espinosa-Garcia C, Sergeeva E, Stein D. Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma. Scientific Reports 2019, 9: 988. PMID: 30700763, PMCID: PMC6353890, DOI: 10.1038/s41598-018-37399-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApoptosisBehavior, AnimalBiomarkersCell Line, TumorCell ProliferationCell SurvivalCellular SenescenceEnzyme AssaysGlioblastomaGlycolysisLuciferasesMice, NudeModels, BiologicalMotor ActivityNeovascularization, PathologicPhosphatidylinositol 3-KinasesProgesteroneProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesConceptsGrowth of glioblastoma multiformeGlycolytic metabolismEffect of progesterone treatmentHigh-dose progesteroneReduced anxiety-like behaviorFollow-up in vitro studyOrthotopic mouse modelSpontaneous locomotor activityAnxiety-like behaviorAthymic nude miceInduce senescenceExpression of GLUT1Increased survival rateCytoplasmic FOXO1Tumor sizeTumor establishmentProgesterone administrationProgesterone treatmentTumor cellsTumor progressionInduce premature senescenceFollow-upNude micePeripheral organsLocomotor activity
2016
Disruption of motor behavior and injury to the CNS induced by 3-thienylboronic acid in mice
Farfán-García E, Pérez-Rodríguez M, Espinosa-García C, Castillo-Mendieta N, Maldonado-Castro M, Querejeta E, Trujillo-Ferrara J, Soriano-Ursúa M. Disruption of motor behavior and injury to the CNS induced by 3-thienylboronic acid in mice. Toxicology And Applied Pharmacology 2016, 307: 130-137. PMID: 27495897, DOI: 10.1016/j.taap.2016.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBoronic AcidsBrainDimethyl SulfoxideMaleMice, Inbred C57BLMotor ActivityNeuronsToxicity Tests, AcuteTremorConceptsCentral nervous systemDisruption of motor activityDose of 400mg/kgMotor disruptionLoss of neuronsCD1 miceIntraperitoneal administrationMotor behaviorMotor activitySubstantia nigraNervous systemDoseMiceMotor performanceMotor systemCell damageMotor cortexNeurotoxic agentsInjuryBoron-free compoundsEffects of BCCAdministrationScarcity of studies