2020
Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus
Varvel N, Espinosa-Garcia C, Hunter-Chang S, Chen D, Biegel A, Hsieh A, Blackmer-Raynolds L, Ganesh T, Dingledine R. Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus. Journal Of Neuroscience 2020, 41: 1105-1117. PMID: 33293358, PMCID: PMC7880294, DOI: 10.1523/jneurosci.2040-20.2020.Peer-Reviewed Original ResearchConceptsBlood-brain barrierImmune myeloid cellsEP2 receptorInnate immune cellsStatus epilepticusEP2 antagonismProstaglandin EP2 receptorBlood-borne monocytesMyeloid cellsImmune cellsConsequences of seizuresBrain infiltrationInflammatory cytokinesFormation of inflammatory cytokinesConditional KOInflammatory responsePeripheral innate immune cellsActivation of EP2 receptorsQuality of lifeEP2 receptor antagonistRecruitment of blood-borne monocytesSerum albumin levelPeripheral immune cellsConsequences of status epilepticusHippocampal IL-6
2018
Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury
Sergeeva E, Espinosa-Garcia C, Atif F, Pardue M, Stein D. Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury. Experimental Neurology 2018, 306: 138-148. PMID: 29729249, PMCID: PMC6021019, DOI: 10.1016/j.expneurol.2018.05.005.Peer-Reviewed Original ResearchConceptsOptic nerve crush injuryNeurosteroid allopregnanoloneIntact eyeTherapeutic potential of allopregnanoloneUnilateral optic nerve injuryOptic nerve injuryPost-injury days 3Enhancement of visual responsesSpatial frequency thresholdsNerve crush injuryIpsilateral visual cortexHyper-activityExperience-dependent plasticityVisual cortexModulation of plasticityGABA inhibitionNerve injuryAdult miceSide ipsilateralAllopregnanoloneDay 3Crush injuryCrushed nervesTreated animalsTherapeutic potential
2016
Disruption of motor behavior and injury to the CNS induced by 3-thienylboronic acid in mice
Farfán-García E, Pérez-Rodríguez M, Espinosa-García C, Castillo-Mendieta N, Maldonado-Castro M, Querejeta E, Trujillo-Ferrara J, Soriano-Ursúa M. Disruption of motor behavior and injury to the CNS induced by 3-thienylboronic acid in mice. Toxicology And Applied Pharmacology 2016, 307: 130-137. PMID: 27495897, DOI: 10.1016/j.taap.2016.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBoronic AcidsBrainDimethyl SulfoxideMaleMice, Inbred C57BLMotor ActivityNeuronsToxicity Tests, AcuteTremorConceptsCentral nervous systemDisruption of motor activityDose of 400mg/kgMotor disruptionLoss of neuronsCD1 miceIntraperitoneal administrationMotor behaviorMotor activitySubstantia nigraNervous systemDoseMiceMotor performanceMotor systemCell damageMotor cortexNeurotoxic agentsInjuryBoron-free compoundsEffects of BCCAdministrationScarcity of studies