Featured Publications
Impact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review
Espinosa-Garcia C, Zeleke H, Rojas A. Impact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review. International Journal Of Molecular Sciences 2021, 22: 4061. PMID: 33920037, PMCID: PMC8071059, DOI: 10.3390/ijms22084061.Peer-Reviewed Original ResearchConceptsImpact of stressChronic stressPsychiatric comorbidityPsychiatric comorbiditiesStressor durationDepressive stateAcute stressPoor quality of lifeBrain damageSeizure occurrencePreclinical researchSeizure triggersOutcome severityDisordersEpilepsy outcomeEpilepsy patientsRecurrent seizuresEpilepsyNeurological disordersQuality of lifeSeizuresDeleterious impactDepressionComorbidity
2024
Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology
Kumar P, Goettemoeller A, Espinosa-Garcia C, Tobin B, Tfaily A, Nelson R, Natu A, Dammer E, Santiago J, Malepati S, Cheng L, Xiao H, Duong D, Seyfried N, Wood L, Rowan M, Rangaraju S. Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology. Nature Communications 2024, 15: 2823. PMID: 38561349, PMCID: PMC10985119, DOI: 10.1038/s41467-024-47028-7.Peer-Reviewed Original ResearchConceptsBiotinylation of proteinsAlzheimer's diseasePre-synaptic defectsDecreased mTOR signalingAD pathogenesisAD riskCytoskeletal disruptionProteomic alterationsTranslational activityMolecular insightsMTOR signalingProteomic findingsProteomicsProteomic signatureMolecular signaturesProteinOver-representedProgressive neuropathologyAlzheimer pathologyMouse modelPV-INsParvalbumin interneuronsMitochondriaAssociated with cognitive declineFast-spiking parvalbumin interneurons
2021
Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
Bonilla-Jaime H, Zeleke H, Rojas A, Espinosa-Garcia C. Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link. International Journal Of Molecular Sciences 2021, 22: 12531. PMID: 34830412, PMCID: PMC8617844, DOI: 10.3390/ijms222212531.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep deprivationAnti-epileptic drugsEpilepsy-related mortalitySudden unexpected deathPotential mechanistic linkSleep apneaImprove quality of lifeWorsen neurodegenerationDaytime sleepinessDisease progressionSeizure frequencySeizure activityNocturnal seizuresSide effectsQuality of lifeUnexpected deathEpileptic brainSeizuresEpilepsy patientsPoor sleep qualityEpilepsyNeuroinflammationSleep disturbanceMechanistic linkProgesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells
Atif F, Yousuf S, Espinosa-Garcia C, Stein D. Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells. Molecular Neurobiology 2021, 58: 3805-3816. PMID: 33847913, DOI: 10.1007/s12035-021-02382-1.Peer-Reviewed Original ResearchConceptsExtracellular acidification rateEffects of P4Glioblastoma multiformeGlioblastoma multiforme cell linesGlioblastoma multiforme cellsCell linesInhibitory effectDecreased tumor sizeSuperoxide radical generationMitochondrial functionDose-dependent inhibitory effectOxygen consumption rateTime-response studiesMitochondrial respirationHuman glioblastoma multiformeMitochondrial stress testSpread of glioblastoma multiformeCompared to controlsTumor sizeConcentrations of P4Human glioblastoma cellsModulate mitochondrial functionNonmitochondrial oxygen consumptionMaximum inhibitory effectDose response
2017
Goldstein et al.'s Secondary Analysis of Progesterone Clinical Trial for Traumatic Brain Injury Can Only Reflect the Same Trial Design Flaws: A Response to “Very Early Administration of Progesterone Does Not Improve Neuropsychological Outcomes in Subjects with Moderate to Severe Traumatic Brain Injury”
Stein D, Sayeed I, Espinosa-Garcia C, Atif F, Sergeeva E. Goldstein et al.'s Secondary Analysis of Progesterone Clinical Trial for Traumatic Brain Injury Can Only Reflect the Same Trial Design Flaws: A Response to “Very Early Administration of Progesterone Does Not Improve Neuropsychological Outcomes in Subjects with Moderate to Severe Traumatic Brain Injury”. Journal Of Neurotrauma 2017, 34: 2192-2193. PMID: 28088875, DOI: 10.1089/neu.2016.4949.Peer-Reviewed Original Research
2016
On the Limitations of Progesterone Treatment in Very Severe Traumatic Brain Injury: What Can Be Learned from Allitt et al., “Progesterone Exacerbates Short-Term Effects of Traumatic Brain Injury”
Atif F, Espinosa-Garcia C, Sayeed I, Sergeeva E, Turan N, Wali B, Wright D, Yousuf S, Stein D. On the Limitations of Progesterone Treatment in Very Severe Traumatic Brain Injury: What Can Be Learned from Allitt et al., “Progesterone Exacerbates Short-Term Effects of Traumatic Brain Injury”. Journal Of Neurotrauma 2016, 34: 1488-1489. PMID: 27138302, DOI: 10.1089/neu.2016.4488.Peer-Reviewed Original Research