2022
Preclinical development of an EP2 antagonist for post-seizure cognitive deficits
Varvel N, Amaradhi R, Espinosa-Garcia C, Duddy S, Franklin R, Banik A, Alemán-Ruiz C, Blackmer-Raynolds L, Wang W, Honore T, Ganesh T, Dingledine R. Preclinical development of an EP2 antagonist for post-seizure cognitive deficits. Neuropharmacology 2022, 224: 109356. PMID: 36460083, PMCID: PMC9894535, DOI: 10.1016/j.neuropharm.2022.109356.Peer-Reviewed Original ResearchConceptsCognitive deficitsStatus epilepticusY-maze performanceInvestigational new drugEP2 antagonistComorbidities of epilepsyReduced delayed mortalityY-mazeCognitive comorbiditiesBlood-brain barrier leakageDays of oral administrationCOX-2 inductionSigns of toxicityDeficitsIn vitro studiesEP2 receptorReceptor modulatorsDose linearityProstaglandin E2Neuronal injuryPreclinical developmentOral administrationPreventive treatmentHistopathological signsCyclooxygenase-2
2020
Sex differences in the performance of cognitive tasks in a murine model of metabolic syndrome
Espinosa‐García C, Fuentes‐Venado C, Guerra‐Araiza C, Segura‐Uribe J, Chávez‐Gutiérrez E, Farfán‐García E, Cruz N, Pinto‐Almazán R. Sex differences in the performance of cognitive tasks in a murine model of metabolic syndrome. European Journal Of Neuroscience 2020, 52: 2724-2736. PMID: 32302458, DOI: 10.1111/ejn.14751.Peer-Reviewed Original ResearchConceptsCognitive impairmentSpatial learningLong-term memory impairmentPerformance of cognitive tasksFemale ratsLong-term memoryAssess cognitive impairmentSprague-Dawley maleMetabolic syndromeHypercaloric dietMemory impairmentSpatial memoryCognitive tasksCognitive differencesSex differencesCA1 regionCountless reportsMetS animal modelMale ratsModel of metabolic syndromeControl groupImpairmentMurine model of metabolic syndromeStandard chow dietMemory
2011
Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia.
Moralí G, Montes P, Hernández-Morales L, Monfil T, Espinosa-García C, Cervantes M. Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia. Restorative Neurology And Neuroscience 2011, 29: 1-15. PMID: 21335664, DOI: 10.3233/rnn-2011-0571.Peer-Reviewed Original ResearchConceptsNeuroprotective effects of progesteroneEffects of progesteroneTreated ratsGlobal cerebral ischemiaLoss of hippocampal pyramidal neuronsPyramidal neuronsLong-term cognitive outcomesCerebral ischemiaAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsLoss of pyramidal neuronsHippocampal pyramidal neuronsSprague-Dawley ratsWorking memoryMemory testTreated with P4Spatial learningCognitive outcomesAllopregnanoloneNeural conditionsIntact ratsHippocampusSham procedureForebrain ischemiaNonischemic controls