2021
Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells
Atif F, Yousuf S, Espinosa-Garcia C, Stein D. Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells. Molecular Neurobiology 2021, 58: 3805-3816. PMID: 33847913, DOI: 10.1007/s12035-021-02382-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorEnergy MetabolismGlioblastomaHumansMitochondriaOxygen ConsumptionProgesteroneSmegmamorphaConceptsExtracellular acidification rateEffects of P4Glioblastoma multiformeGlioblastoma multiforme cell linesGlioblastoma multiforme cellsCell linesInhibitory effectDecreased tumor sizeSuperoxide radical generationMitochondrial functionDose-dependent inhibitory effectOxygen consumption rateTime-response studiesMitochondrial respirationHuman glioblastoma multiformeMitochondrial stress testSpread of glioblastoma multiformeCompared to controlsTumor sizeConcentrations of P4Human glioblastoma cellsModulate mitochondrial functionNonmitochondrial oxygen consumptionMaximum inhibitory effectDose response
2019
Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma
Atif F, Yousuf S, Espinosa-Garcia C, Sergeeva E, Stein D. Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma. Scientific Reports 2019, 9: 988. PMID: 30700763, PMCID: PMC6353890, DOI: 10.1038/s41598-018-37399-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApoptosisBehavior, AnimalBiomarkersCell Line, TumorCell ProliferationCell SurvivalCellular SenescenceEnzyme AssaysGlioblastomaGlycolysisLuciferasesMice, NudeModels, BiologicalMotor ActivityNeovascularization, PathologicPhosphatidylinositol 3-KinasesProgesteroneProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesConceptsGrowth of glioblastoma multiformeGlycolytic metabolismEffect of progesterone treatmentHigh-dose progesteroneReduced anxiety-like behaviorFollow-up in vitro studyOrthotopic mouse modelSpontaneous locomotor activityAnxiety-like behaviorAthymic nude miceInduce senescenceExpression of GLUT1Increased survival rateCytoplasmic FOXO1Tumor sizeTumor establishmentProgesterone administrationProgesterone treatmentTumor cellsTumor progressionInduce premature senescenceFollow-upNude micePeripheral organsLocomotor activity