Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury
Sergeeva E, Espinosa-Garcia C, Atif F, Pardue M, Stein D. Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury. Experimental Neurology 2018, 306: 138-148. PMID: 29729249, PMCID: PMC6021019, DOI: 10.1016/j.expneurol.2018.05.005.Peer-Reviewed Original ResearchConceptsOptic nerve crush injuryNeurosteroid allopregnanoloneIntact eyeTherapeutic potential of allopregnanoloneUnilateral optic nerve injuryOptic nerve injuryPost-injury days 3Enhancement of visual responsesSpatial frequency thresholdsNerve crush injuryIpsilateral visual cortexHyper-activityExperience-dependent plasticityVisual cortexModulation of plasticityGABA inhibitionNerve injuryAdult miceSide ipsilateralAllopregnanoloneDay 3Crush injuryCrushed nervesTreated animalsTherapeutic potential