2020
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury. International Journal Of Molecular Sciences 2020, 21: 3740. PMID: 32466385, PMCID: PMC7312827, DOI: 10.3390/ijms21113740.Peer-Reviewed Original ResearchConceptsHigh-mobility group box 1HMGB1 releaseIschemic brain injuryNLRP3 inflammasome activationExposed to social defeat stressGlobal ischemiaIschemic animalsAssociated with cardiac arrestInflammasome activationAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsNeonatal brain tissueHippocampus of ischemic animalsRodent models of cerebral ischemiaSocial defeat stressRelease of alarminsModels of cerebral ischemiaSprague-Dawley ratsBrain injuryNOD-like receptor pyrin domainNLRP3 inflammasomeResponse to ischemiaPrimed with lipopolysaccharideBlocks progesteroneDays post-ischemia
2019
Abstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Abstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp150.Peer-Reviewed Original ResearchLC3 punctaLC3-IIP62 levelsLC3-II levelsAutophagy inhibitorLC3 levelsIschemic animalsExposed to social defeat stressComorbid stressGlobal ischemiaMicroglial autophagyInflammatory responseCerebral ischemiaLC3Progesterone's protective effectsAutophagic fluxRodent models of cerebral ischemiaP62Social defeat stressExaggerated inflammatory responseAdult male ratsModels of cerebral ischemiaNLRP3 inflammasome overactivationNon-ischemic controlsTreated with progesterone