Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury
Espinosa-Garcia C, Sayeed I, Atif F, Yousuf S, Neigh G, Stein D. Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wp101.Peer-Reviewed Original ResearchSocial stressExposure to social stressExposed to social defeat stressSocial defeat stressNLRP3 inflammasome activationSensitive to stressInflammasome activationAdult male ratsGlobal ischemiaDefeat stressIschemic animalsComorbid stressIschemic injuryConsistent with previous reportsConsequences of cardiac arrestRelease of danger signalsNon-ischemic controlsMicroglial primingCaspase-1IL-1b levelsMale ratsDays post-ischemiaHippocampusCleaved caspase-1Poor outcome