Featured Publications
Stress primes microglial polarization after global ischemia: Therapeutic potential of progesterone
Espinosa-Garcia C, Sayeed I, Yousuf S, Atif F, Sergeeva E, Neigh G, Stein D. Stress primes microglial polarization after global ischemia: Therapeutic potential of progesterone. Brain Behavior And Immunity 2017, 66: 177-192. PMID: 28648389, DOI: 10.1016/j.bbi.2017.06.012.Peer-Reviewed Original ResearchConceptsAnti-inflammatory cytokinesGlobal ischemiaDays of social defeat stressIncreased pro-inflammatory cytokine expressionPost-ischemiaIntraperitoneal injections of progesteroneNeuroprotective effects of progesteroneMale Sprague-Dawley ratsIschemic strokeAssociated with increased riskMicroglial polarizationSocial defeat stressCA1 hippocampal regionEffects of progesteroneAssociated with increased risk of strokePro-inflammatory cytokine expressionSprague-Dawley ratsNeurotrophic factor expressionInjection of progesteroneAnti-inflammatory mediatorsPro-inflammatory cytokinesExacerbate neuronal lossRisk of strokeM2 phenotype markersPotential therapeutic strategy
2017
Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone
Espinosa-Garcia C, Sayeed I, Yousuf S, Atif F, Sergeeva E, Neigh G, Stein D. Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone. Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.tp83.Peer-Reviewed Original ResearchPro-inflammatory cytokinesNeuronal lossExposed to social defeat stressGlobal ischemiaIncreased brain-derived neurotrophic factor expressionInflammatory responsePost-ischemiaFactor expressionPost-ischemic inflammatory responseBrain-derived neurotrophic factor expressionAssociated with increased riskSocial defeat stressIschemia-induced inflammatory responseAdult male ratsAssociated with increased risk of strokeFour-vessel occlusion modelNeurotrophic factor expressionGrowth factor expressionHippocampal CA1 regionGlobal ischemic injuryActivation of microgliaExacerbated microglial activationRisk of strokeDays post-ischemiaDefeat stress