Age‐Dependent Changes in Perineuronal Nets and Associated Parvalbumin Interneurons in the 5xFAD Amyloidosis Mouse Model
Nelson R, Rangaraju S, Rayaprolu S, Kumar P, Espinosa‐Garcia C, Xiao H. Age‐Dependent Changes in Perineuronal Nets and Associated Parvalbumin Interneurons in the 5xFAD Amyloidosis Mouse Model. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.083101.Peer-Reviewed Original ResearchPV+ neuronsWild typePerineuronal netsAlzheimer's diseaseAD-like pathologyCo-localizationMouse modelAmyloid-betaFast-spiking interneuronsEarly amyloidosisRegulate synaptic transmissionSynaptic maintenanceExtracellular matrix structurePlaque proximityAge-dependent mannerMonths of agePhysiological roleImmunofluorescence microscopyNeuronal roleNeurodegenerative diseasesParvalbumin-positiveParvalbumin interneuronsAge-dependent changesSynaptic transmissionProximal dendrites