2020
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury. International Journal Of Molecular Sciences 2020, 21: 3740. PMID: 32466385, PMCID: PMC7312827, DOI: 10.3390/ijms21113740.Peer-Reviewed Original ResearchConceptsHigh-mobility group box 1HMGB1 releaseIschemic brain injuryNLRP3 inflammasome activationExposed to social defeat stressGlobal ischemiaIschemic animalsAssociated with cardiac arrestInflammasome activationAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsNeonatal brain tissueHippocampus of ischemic animalsRodent models of cerebral ischemiaSocial defeat stressRelease of alarminsModels of cerebral ischemiaSprague-Dawley ratsBrain injuryNOD-like receptor pyrin domainNLRP3 inflammasomeResponse to ischemiaPrimed with lipopolysaccharideBlocks progesteroneDays post-ischemia
2018
Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury
Espinosa-Garcia C, Sayeed I, Atif F, Yousuf S, Neigh G, Stein D. Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wp101.Peer-Reviewed Original ResearchSocial stressExposure to social stressExposed to social defeat stressSocial defeat stressNLRP3 inflammasome activationSensitive to stressInflammasome activationAdult male ratsGlobal ischemiaDefeat stressIschemic animalsComorbid stressIschemic injuryConsistent with previous reportsConsequences of cardiac arrestRelease of danger signalsNon-ischemic controlsMicroglial primingCaspase-1IL-1b levelsMale ratsDays post-ischemiaHippocampusCleaved caspase-1Poor outcome