Abstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Abstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp150.Peer-Reviewed Original ResearchLC3 punctaLC3-IIP62 levelsLC3-II levelsAutophagy inhibitorLC3 levelsIschemic animalsExposed to social defeat stressComorbid stressGlobal ischemiaMicroglial autophagyInflammatory responseCerebral ischemiaLC3Progesterone's protective effectsAutophagic fluxRodent models of cerebral ischemiaP62Social defeat stressExaggerated inflammatory responseAdult male ratsModels of cerebral ischemiaNLRP3 inflammasome overactivationNon-ischemic controlsTreated with progesterone