Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone
Espinosa-Garcia C, Sayeed I, Yousuf S, Atif F, Sergeeva E, Neigh G, Stein D. Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone. Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.tp83.Peer-Reviewed Original ResearchPro-inflammatory cytokinesNeuronal lossExposed to social defeat stressGlobal ischemiaIncreased brain-derived neurotrophic factor expressionInflammatory responsePost-ischemiaFactor expressionPost-ischemic inflammatory responseBrain-derived neurotrophic factor expressionAssociated with increased riskSocial defeat stressIschemia-induced inflammatory responseAdult male ratsAssociated with increased risk of strokeFour-vessel occlusion modelNeurotrophic factor expressionGrowth factor expressionHippocampal CA1 regionGlobal ischemic injuryActivation of microgliaExacerbated microglial activationRisk of strokeDays post-ischemiaDefeat stress