2020
Post-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone
Atif F, Yousuf S, Espinosa-Garcia C, Harris W, Stein D. Post-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone. Neuropharmacology 2020, 181: 108327. PMID: 32950558, DOI: 10.1016/j.neuropharm.2020.108327.Peer-Reviewed Original ResearchConceptsPeripheral immune dysfunctionVitamin D hormoneTransient middle cerebral artery occlusion/reperfusionImmune dysfunctionSystemic inflammationInfarct volumeSubsets of immune cellsNeuronal inflammationMeasure infarct volumePost-stroke infectionsInjection of lipopolysaccharideIn-hospital infectionStandard of careFlow cytometric analysisMiddle cerebral artery occlusion/reperfusionCleaved caspase-3Combination therapyInflammation groupImmune cellsAdult ratsIncreased morbidityD hormoneBrain post-strokeImmunomodulatory effectsCombined treatment
2019
Abstract TMP32: Post-Stroke Systemic Inflammation: Immunomodulation by Progesterone and Vitamin D Hormone
Atif F, Yousuf S, Harris W, Espinosa-Garcia C, Stein D. Abstract TMP32: Post-Stroke Systemic Inflammation: Immunomodulation by Progesterone and Vitamin D Hormone. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.tmp32.Peer-Reviewed Original ResearchTransient middle cerebral artery occlusion/reperfusionPeripheral immune dysfunctionVitamin D hormoneSystemic inflammationImmune dysfunctionD hormoneAdult male Sprague-Dawley ratsSubsets of immune cellsTukey HSD post hoc testMale Sprague-Dawley ratsNeuronal inflammationFunctional deficitsPost-stroke infectionsSpontaneous locomotor activitySprague-Dawley ratsInjection of lipopolysaccharideStandard of careCombination of P4Flow cytometric analysisMiddle cerebral artery occlusion/reperfusionPost hoc testSham + vehicleImproving functional deficitsCombination therapySham surgery