Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia
Bowen C, Nguyen H, Lin Y, Bagchi P, Natu A, Espinosa-Garcia C, Werner E, Kumari R, Brandelli A, Kumar P, Tobin B, Wood L, Faundez V, Wulff H, Seyfried N, Rangaraju S. Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia. Molecular & Cellular Proteomics 2024, 23: 100809. PMID: 38936775, DOI: 10.1016/j.mcpro.2024.100809.Peer-Reviewed Original ResearchDisease-associated microgliaPDZ-binding domainImmune signaling proteinsInflammatory responseProinflammatory signaling moleculesInhibition of Kv1.3Resident immune cellsSignaling proteinsKv1.3 potassium channelsC-terminusC-terminal PDZ-binding domainMicroglia transitionTLR4-mediated activationLipopolysaccharide-induced inflammatory responseKv1.3 blockadeImmune cellsPotential interacting proteinsInflammatory statePotassium channelsInflammatory contextKv1.3Flux of potassium ionsTLR4-induced inflammatory responsesFlow cytometryGlycolytic response