2020
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury. International Journal Of Molecular Sciences 2020, 21: 3740. PMID: 32466385, PMCID: PMC7312827, DOI: 10.3390/ijms21113740.Peer-Reviewed Original ResearchConceptsHigh-mobility group box 1HMGB1 releaseIschemic brain injuryNLRP3 inflammasome activationExposed to social defeat stressGlobal ischemiaIschemic animalsAssociated with cardiac arrestInflammasome activationAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsNeonatal brain tissueHippocampus of ischemic animalsRodent models of cerebral ischemiaSocial defeat stressRelease of alarminsModels of cerebral ischemiaSprague-Dawley ratsBrain injuryNOD-like receptor pyrin domainNLRP3 inflammasomeResponse to ischemiaPrimed with lipopolysaccharideBlocks progesteroneDays post-ischemia
2017
Goldstein et al.'s Secondary Analysis of Progesterone Clinical Trial for Traumatic Brain Injury Can Only Reflect the Same Trial Design Flaws: A Response to “Very Early Administration of Progesterone Does Not Improve Neuropsychological Outcomes in Subjects with Moderate to Severe Traumatic Brain Injury”
Stein D, Sayeed I, Espinosa-Garcia C, Atif F, Sergeeva E. Goldstein et al.'s Secondary Analysis of Progesterone Clinical Trial for Traumatic Brain Injury Can Only Reflect the Same Trial Design Flaws: A Response to “Very Early Administration of Progesterone Does Not Improve Neuropsychological Outcomes in Subjects with Moderate to Severe Traumatic Brain Injury”. Journal Of Neurotrauma 2017, 34: 2192-2193. PMID: 28088875, DOI: 10.1089/neu.2016.4949.Peer-Reviewed Original Research
2016
On the Limitations of Progesterone Treatment in Very Severe Traumatic Brain Injury: What Can Be Learned from Allitt et al., “Progesterone Exacerbates Short-Term Effects of Traumatic Brain Injury”
Atif F, Espinosa-Garcia C, Sayeed I, Sergeeva E, Turan N, Wali B, Wright D, Yousuf S, Stein D. On the Limitations of Progesterone Treatment in Very Severe Traumatic Brain Injury: What Can Be Learned from Allitt et al., “Progesterone Exacerbates Short-Term Effects of Traumatic Brain Injury”. Journal Of Neurotrauma 2016, 34: 1488-1489. PMID: 27138302, DOI: 10.1089/neu.2016.4488.Peer-Reviewed Original Research