2018
Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury
Sergeeva E, Espinosa-Garcia C, Atif F, Pardue M, Stein D. Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury. Experimental Neurology 2018, 306: 138-148. PMID: 29729249, PMCID: PMC6021019, DOI: 10.1016/j.expneurol.2018.05.005.Peer-Reviewed Original ResearchConceptsOptic nerve crush injuryNeurosteroid allopregnanoloneIntact eyeTherapeutic potential of allopregnanoloneUnilateral optic nerve injuryOptic nerve injuryPost-injury days 3Enhancement of visual responsesSpatial frequency thresholdsNerve crush injuryIpsilateral visual cortexHyper-activityExperience-dependent plasticityVisual cortexModulation of plasticityGABA inhibitionNerve injuryAdult miceSide ipsilateralAllopregnanoloneDay 3Crush injuryCrushed nervesTreated animalsTherapeutic potential
2011
Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia.
Moralí G, Montes P, Hernández-Morales L, Monfil T, Espinosa-García C, Cervantes M. Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia. Restorative Neurology And Neuroscience 2011, 29: 1-15. PMID: 21335664, DOI: 10.3233/rnn-2011-0571.Peer-Reviewed Original ResearchConceptsNeuroprotective effects of progesteroneEffects of progesteroneTreated ratsGlobal cerebral ischemiaLoss of hippocampal pyramidal neuronsPyramidal neuronsLong-term cognitive outcomesCerebral ischemiaAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsLoss of pyramidal neuronsHippocampal pyramidal neuronsSprague-Dawley ratsWorking memoryMemory testTreated with P4Spatial learningCognitive outcomesAllopregnanoloneNeural conditionsIntact ratsHippocampusSham procedureForebrain ischemiaNonischemic controls