2019
Abstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Abstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp150.Peer-Reviewed Original ResearchLC3 punctaLC3-IIP62 levelsLC3-II levelsAutophagy inhibitorLC3 levelsIschemic animalsExposed to social defeat stressComorbid stressGlobal ischemiaMicroglial autophagyInflammatory responseCerebral ischemiaLC3Progesterone's protective effectsAutophagic fluxRodent models of cerebral ischemiaP62Social defeat stressExaggerated inflammatory responseAdult male ratsModels of cerebral ischemiaNLRP3 inflammasome overactivationNon-ischemic controlsTreated with progesterone
2018
Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury
Espinosa-Garcia C, Sayeed I, Atif F, Yousuf S, Neigh G, Stein D. Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wp101.Peer-Reviewed Original ResearchSocial stressExposure to social stressExposed to social defeat stressSocial defeat stressNLRP3 inflammasome activationSensitive to stressInflammasome activationAdult male ratsGlobal ischemiaDefeat stressIschemic animalsComorbid stressIschemic injuryConsistent with previous reportsConsequences of cardiac arrestRelease of danger signalsNon-ischemic controlsMicroglial primingCaspase-1IL-1b levelsMale ratsDays post-ischemiaHippocampusCleaved caspase-1Poor outcome
2017
Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone
Espinosa-Garcia C, Sayeed I, Yousuf S, Atif F, Sergeeva E, Neigh G, Stein D. Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone. Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.tp83.Peer-Reviewed Original ResearchPro-inflammatory cytokinesNeuronal lossExposed to social defeat stressGlobal ischemiaIncreased brain-derived neurotrophic factor expressionInflammatory responsePost-ischemiaFactor expressionPost-ischemic inflammatory responseBrain-derived neurotrophic factor expressionAssociated with increased riskSocial defeat stressIschemia-induced inflammatory responseAdult male ratsAssociated with increased risk of strokeFour-vessel occlusion modelNeurotrophic factor expressionGrowth factor expressionHippocampal CA1 regionGlobal ischemic injuryActivation of microgliaExacerbated microglial activationRisk of strokeDays post-ischemiaDefeat stress
2013
Effects of progesterone on neurite growth inhibitors in the hippocampus following global cerebral ischemia
Espinosa-García C, Aguilar-Hernández A, Cervantes M, Moralí G. Effects of progesterone on neurite growth inhibitors in the hippocampus following global cerebral ischemia. Brain Research 2013, 1545: 23-34. PMID: 24316245, DOI: 10.1016/j.brainres.2013.11.030.Peer-Reviewed Original ResearchConceptsEffects of progesteroneGlobal cerebral ischemiaMorris water mazeCA1 pyramidal neuronsNogo-ACerebral ischemiaPyramidal neuronsRho ACell bodies of CA1 pyramidal neuronsNeurite growth inhibitor Nogo-ASpatial learningVehicle-treated ratsAdult male ratsTreated with P4Effects of P4Dendritic arborization of CA1 pyramidal neuronsAssociated with parametersNeurite growth inhibitorsFunction preservationMale ratsRat hippocampusWater mazeIschemiaHippocampal layersRats