2020
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury. International Journal Of Molecular Sciences 2020, 21: 3740. PMID: 32466385, PMCID: PMC7312827, DOI: 10.3390/ijms21113740.Peer-Reviewed Original ResearchConceptsHigh-mobility group box 1HMGB1 releaseIschemic brain injuryNLRP3 inflammasome activationExposed to social defeat stressGlobal ischemiaIschemic animalsAssociated with cardiac arrestInflammasome activationAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsNeonatal brain tissueHippocampus of ischemic animalsRodent models of cerebral ischemiaSocial defeat stressRelease of alarminsModels of cerebral ischemiaSprague-Dawley ratsBrain injuryNOD-like receptor pyrin domainNLRP3 inflammasomeResponse to ischemiaPrimed with lipopolysaccharideBlocks progesteroneDays post-ischemia
2019
Abstract TMP32: Post-Stroke Systemic Inflammation: Immunomodulation by Progesterone and Vitamin D Hormone
Atif F, Yousuf S, Harris W, Espinosa-Garcia C, Stein D. Abstract TMP32: Post-Stroke Systemic Inflammation: Immunomodulation by Progesterone and Vitamin D Hormone. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.tmp32.Peer-Reviewed Original ResearchTransient middle cerebral artery occlusion/reperfusionPeripheral immune dysfunctionVitamin D hormoneSystemic inflammationImmune dysfunctionD hormoneAdult male Sprague-Dawley ratsSubsets of immune cellsTukey HSD post hoc testMale Sprague-Dawley ratsNeuronal inflammationFunctional deficitsPost-stroke infectionsSpontaneous locomotor activitySprague-Dawley ratsInjection of lipopolysaccharideStandard of careCombination of P4Flow cytometric analysisMiddle cerebral artery occlusion/reperfusionPost hoc testSham + vehicleImproving functional deficitsCombination therapySham surgery
2013
Post-ischemic administration of progesterone reduces caspase-3 activation and DNA fragmentation in the hippocampus following global cerebral ischemia
Espinosa-García C, Vigueras-Villaseñor R, Rojas-Castañeda J, Aguilar-Hernández A, Monfil T, Cervantes M, Moralí G. Post-ischemic administration of progesterone reduces caspase-3 activation and DNA fragmentation in the hippocampus following global cerebral ischemia. Neuroscience Letters 2013, 550: 98-103. PMID: 23810799, DOI: 10.1016/j.neulet.2013.06.023.Peer-Reviewed Original ResearchConceptsCaspase-3 levelsGlobal cerebral ischemia/reperfusionCaspase-3Pyramidal neuronsCaspase-3 activityAdult male Sprague-Dawley ratsHippocampal CA1 pyramidal neuronsNeuroprotective effects of progesteroneCerebral ischemia/reperfusionMale Sprague-Dawley ratsGlobal cerebral ischemia/reperfusion injuryCA1 pyramidal neuronsNeuroprotective effectsEffects of progesteroneAdministration of progesteroneIschemia/reperfusion-induced increasesSprague-Dawley ratsFour-vessel occlusion modelModels of brain injuryEffects of P4CA1 neuronal lossGlobal cerebral ischemiaPost-ischemic administrationCerebral ischemia/reperfusion injuryDNA fragmentation
2011
Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia.
Moralí G, Montes P, Hernández-Morales L, Monfil T, Espinosa-García C, Cervantes M. Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia. Restorative Neurology And Neuroscience 2011, 29: 1-15. PMID: 21335664, DOI: 10.3233/rnn-2011-0571.Peer-Reviewed Original ResearchConceptsNeuroprotective effects of progesteroneEffects of progesteroneTreated ratsGlobal cerebral ischemiaLoss of hippocampal pyramidal neuronsPyramidal neuronsLong-term cognitive outcomesCerebral ischemiaAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsLoss of pyramidal neuronsHippocampal pyramidal neuronsSprague-Dawley ratsWorking memoryMemory testTreated with P4Spatial learningCognitive outcomesAllopregnanoloneNeural conditionsIntact ratsHippocampusSham procedureForebrain ischemiaNonischemic controls