Responsive Neurostimulation for People With Drug-Resistant Epilepsy and Autism Spectrum Disorder
Fields M, Marsh C, Eka O, Johnson E, Marcuse L, Kwon C, Young J, LaVega-Talbott M, Kurukumbi M, Von Allmen G, Zempel J, Friedman D, Jette N, Singh A, Yoo J, Blank L, Panov F, Ghatan S. Responsive Neurostimulation for People With Drug-Resistant Epilepsy and Autism Spectrum Disorder. Journal Of Clinical Neurophysiology 2023, 41: 64-71. PMID: 35512185, PMCID: PMC10756699, DOI: 10.1097/wnp.0000000000000939.Peer-Reviewed Original ResearchConceptsDrug-resistant epilepsySuper respondersSeizure reductionPromising surgical optionResponsive neurostimulator systemRNS SystemAutism spectrum disorderSurgical candidatesSurgical evaluationSurgical optionsMulticenter studySpectrum disorderGeneral populationResponsive neurostimulationPatientsResponse rateSmall cohortEpilepsyNeurostimulator systemHigh rateRespondersDescriptive statisticsSystem placementBehavioral outcomesDisordersA multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
Fields M, Eka O, Schreckinger C, Dugan P, Asaad W, Blum A, Bullinger K, Willie J, Burdette D, Anderson C, Quraishi I, Gerrard J, Singh A, Lee K, Yoo J, Ghatan S, Panov F, Marcuse L. A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation. Frontiers In Neurology 2023, 14: 1202631. PMID: 37745648, PMCID: PMC10516547, DOI: 10.3389/fneur.2023.1202631.Peer-Reviewed Original ResearchAnterior thalamic nucleiSerious adverse eventsGlobal Clinical Impression ScaleVagal nerve stimulationDrug-resistant epilepsyDeep brain stimulationAdverse eventsMost patientsResponsive neurostimulationSeizure reductionResective surgeryResistant epilepsyImpression ScaleSide effectsMedian baseline seizure frequencyDrug-resistant epilepsy patientsRare serious adverse eventsAnti-seizure medicationsDifferent epilepsy centersMeaningful seizure reductionMedian seizure reductionMedication regimen changesBaseline seizure frequencyMulticenter retrospective studyRetrospective multicenter study