Raising Endogenous Anti-HMGB1 IgM Antibody for Athero-Protection in the Apoe−/− Mouse Model of Atherosclerosis
Hariharasubramanian A, Elangovan R, Shankar A, Giacobazzi M, Broski A, Panicker A, Shin S, Chen A, Zheng G. Raising Endogenous Anti-HMGB1 IgM Antibody for Athero-Protection in the Apoe−/− Mouse Model of Atherosclerosis. The Journal Of Immunology 2019, 202: 196.30-196.30. DOI: 10.4049/jimmunol.202.supp.196.30.Peer-Reviewed Original ResearchMouse model of atherosclerosisWestern type dietModel of atherosclerosisB cellsIgM antibodiesReduce atherosclerosisIgM-producing B cellsB-1 cellsAnti-atherogenic efficacyNon-treated groupAortic archTreated miceAortic rootC57BL/6 miceApoE-/- mouse modelMouse modelIgM responseWeeks of ageHealthy humansAthero-protectiveMiceAtherosclerosisImmunitySpontaneous productionType diet