2021
Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling
Zhang L, Lin TV, Yuan Q, Sadoul R, Lam TT, Bordey A. Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling. Journal Of Neuroscience 2021, 41: 3799-3807. PMID: 33741723, PMCID: PMC8084316, DOI: 10.1523/jneurosci.0766-20.2021.Peer-Reviewed Original ResearchConceptsSmall extracellular vesiclesRegulation of HDAC2Extracellular vesiclesSpine developmentCell-cell signalingTranscriptional programsCortical neuronsSEV releaseTranscriptional decreaseDendritic spinesNeuronal developmentNeuron developmentDendritic spine developmentLines of evidenceHDAC2Paracrine communicationAge-dependent decreaseVesiclesPopulations of neuronsRegulationLC-MS/MSHDAC2 levelsSynaptic targetsExcitatory synapsesSpine growth
2004
Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons
Huang H, Bordey A. Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons. Journal Of Neuroscience 2004, 24: 5659-5669. PMID: 15215288, PMCID: PMC6729224, DOI: 10.1523/jneurosci.1338-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid Transport System X-AGAnimalsAntiportersCalciumCerebellumCystineEvoked PotentialsGamma-Aminobutyric AcidGlutamic AcidIn Vitro TechniquesMiceNerve FibersNeural InhibitionNeurogliaPatch-Clamp TechniquesPurkinje CellsReceptors, N-Methyl-D-AspartateReceptors, PresynapticRyanodineSynaptic TransmissionConceptsGlial glutamate transportersMiniature IPSCsPurkinje neuronsGlutamate transportersSpontaneous IPSCsSynaptic inhibitionInhibitory synapsesNMDAR activationWhole-cell patch-clamp recordingsPresynaptic NMDA receptorsPaired-pulse ratioMouse cerebellar slicesNMDA receptor activationPresynaptic NMDA receptor activationPatch-clamp recordingsBergmann glial cellsBeta-benzyloxyaspartic acidAdjacent Purkinje neuronsCystine-glutamate antiporterMIPSC frequencyGABAergic terminalsGABAergic synapsesGlial cellsNMDA receptorsExcitatory synapses