Tingting Wang
Associate Research ScientistAbout
Research
Publications
2026
Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease
Qiao S, Fan S, Xu J, Xu Z, Peng C, Qu J, Bing Z, Zhou S, Shen S, Xu G, Zhao Y, Wang T. Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease. Advanced Science 2026, e14830. PMID: 42052722, DOI: 10.1002/advs.202514830.Peer-Reviewed Original ResearchCaspase recruitment domain-containing protein 9S. cerevisiaeAcyl-CoA oxidase 1Caspase recruitment domain-containing protein 9 deficiencyToll-like receptor 1Microbiota-host interactionsGut microbiome differencesSteatotic liver diseaseGut-liver axisAdaptor proteinFatty acid oxidationCarnitine palmitoyltransferase 1AIntestinal microbiotaMicrobiome differencesRecognition receptorsProtein 9Nuclear translocationGlucose homeostasisAryl hydrocarbon receptorMicrobiotaHigh-fat dietAcid oxidationGutAbundanceHepatic steatosisNext-generation in vivo CAR-T expansion strategies: Unlocking durable anti-tumor responses in solid tumors
Sun Z, Wei L, Pan X, Yan W, Wang T, Wang X. Next-generation in vivo CAR-T expansion strategies: Unlocking durable anti-tumor responses in solid tumors. Critical Reviews In Oncology/Hematology 2026, 223: 105342. PMID: 42013999, DOI: 10.1016/j.critrevonc.2026.105342.Peer-Reviewed Original ResearchConceptsCAR-T cellsCAR-TSolid tumorsOuter membrane vesiclesCAR-T cell expansionRisk of disease progressionCAR-T approachAnti-tumor responsesCAR-T therapyCAR-T productsCAR-T manufacturingVaccine platformCell therapyDisease progressionCytokine stimulationTreatment preparationTranslational potentialClinic accessIn vivoIn vitroApplication of nanoparticlesTumorTherapyExpansion platformMembrane vesiclesIntraovarian injection of securinine stimulates the growth of small ovarian follicles by reducing stromal suppression
Zhao Y, Liu D, Lin Z, Deng S, Zhao X, Sun Y, Zhang Y, Zhang Q, Gu J, Xiao Y, Wang T, Lu H, Zhao J, Chan K, Li Y, Yeung W, Liu K. Intraovarian injection of securinine stimulates the growth of small ovarian follicles by reducing stromal suppression. Nature Communications 2026, 17: 5061. PMID: 41974717, PMCID: PMC13243526, DOI: 10.1038/s41467-026-71691-7.Peer-Reviewed Original ResearchConceptsPremature ovarian insufficiencyIntraovarian injectionOvarian insufficiencyOvarian reserveFollicular developmentDevelopment of small folliclesStem cell-based therapiesAdvanced maternal ageCell-based therapiesPlatelet-rich plasmaStromal extracellular matrixAntral folliclesGranulosa cellsMaternal ageSmall folliclesAged miceClinical advantagesOvarian folliclesSingle-cell RNA sequencingHealthy offspringCynomolgus macaquesFollicle growthOvarian injectionFolliclesSmall molecule drugsSelective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor
Zhao X, Yu C, Adamson A, Zhao A, Zhou H, Sharma P, Wang T. Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor. Science Advances 2026, 12: eaeb1134. PMID: 41931622, PMCID: PMC13048245, DOI: 10.1126/sciadv.aeb1134.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsImpaired cell adhesionMonogenetic formsPhosphodiesterase-5Small vessel diseaseMolecular mechanismsCell adhesionPotential drug discoverySynthetic phenotypePhosphodiesterase-5 inhibitionPhosphodiesterase-5 inhibitorsExtracellular matrix accumulationSmooth muscle cellsVessel diseaseNOTCH3 variantsNitric Oxide SignalingVariantsEmbryonic originDrug discoveryOxidation signalDisease modelsFunctional abnormalitiesCADASIL pathogenesisMuscle cellsTherapeutic strategiesPhomones A−C, Anti‐Vibrio α‐Pyrones From Phoma sp. NBUF235 Associated With an Ircinia Sponge From the Marine Mesophotic Zone
Lai T, Li J, Wei T, Zheng Q, Shu K, Khan S, Zhang R, He S, Wang T. Phomones A−C, Anti‐Vibrio α‐Pyrones From Phoma sp. NBUF235 Associated With an Ircinia Sponge From the Marine Mesophotic Zone. Chemistry & Biodiversity 2026, 23: e02573. PMID: 41893952, DOI: 10.1002/cbdv.202502573.Peer-Reviewed Original ResearchConceptsMesophotic zonePhoma sp.Pathogenic bacteria Vibrio harveyiSponge-associated fungiBacteria Vibrio harveyiChemical diversityV. furnissiiV. mimicusV. fluvialisVibrio harveyiV. parahaemolyticusV. choleraeIrcinia sp.Quantum chemistry calculationsSp.Fungus Phoma sp.MIC valuesIrciniaBioassay-guided isolationComprehensive spectroscopic analysesA-CChemistry calculationsCompounds 1Structure elucidationSpectroscopic analysisDiscovery of novel ten-membered lactones as osteoblastogenesis agents targeting Wnt/β-catenin signaling pathway
Zhai Y, Zhang J, Yang J, Wang T, Gao J, Wang W, Han W. Discovery of novel ten-membered lactones as osteoblastogenesis agents targeting Wnt/β-catenin signaling pathway. Bioorganic Chemistry 2026, 175: 109768. PMID: 41865565, DOI: 10.1016/j.bioorg.2026.109768.Peer-Reviewed Original ResearchTen-membered lactoneCrystal X-ray diffractionJ-based configuration analysisOxidative cleavage productsX-ray diffractionModified Mosher's methodDevelopment of lead compoundsLactone unitsRing systemCompound 4Compound 8Lactone monomersCompounds 1Mosher's methodSpectroscopic dataLead compoundsLactoneCompoundsChemical diversityConfiguration analysisDiffractionCleavage productsMonomerDimerCrystalFrom structural evolution to an AI-driven future of 5-HT1F receptor agonists for migraine therapy
Lin L, Wu J, Wang T, Cao Y, Zhang D, Jin H, He S. From structural evolution to an AI-driven future of 5-HT1F receptor agonists for migraine therapy. European Journal Of Medicinal Chemistry 2026, 309: 118768. PMID: 41864040, DOI: 10.1016/j.ejmech.2026.118768.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsReceptor agonistsCentral nervous system adverse effectsClinical approvalInsufficient clinical responseWomen of Childbearing AgeSystemic adverse effectsProportion of patientsAntimigraine therapyClinical responseTrigeminal neuronsMigraine therapyChildbearing ageGlobal disease burdenMigraine managementSmall molecule agonistsMigraineTherapeutic potentialAgonistsTherapyTherapeutic targetDisease burdenAdverse effectsNeurological disordersStructural evolutionIndole-based scaffoldsFree apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst–endometrium interaction in humans
Ruan H, Chen A, Xue Y, Lee K, Fong S, Qiu Q, Tan Y, Feng Y, Lee C, Hua R, Huang J, Wang T, Xu Y, Lee K, Xi N, Li R, Ng E, Yeung W, Lee Y. Free apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst–endometrium interaction in humans. Human Reproduction 2026, 41: 563-582. PMID: 41704048, PMCID: PMC13061149, DOI: 10.1093/humrep/deag009.Peer-Reviewed Original ResearchEndometrial epithelial cellsExpression of CDH1Blastocyst-endometrium interactionHuman blastocystsApical expressionEmbryo-maternal interactionsEndometrial receptivityConditioned mediumImplant failureEmbryonic signalsApical surfaceImmunofluorescence stainingProtein expressionEmbryo attachmentLive birthsApical redistributionTrophectoderm of human blastocystsEpithelial cellsPolar trophectodermEvaluation of endometrial receptivityApical regionEndometrial adenocarcinoma cell lineExpression of adhesion-related moleculesPrimary endometrial epithelial cellsShenzhen Science and Technology ProgramThe Gut–Liver Axis in MASLD: From Host–Microbiome Crosstalk to Precision Therapeutics
Zhou J, Zhu B, Bing Z, Wang T, Zhao Y. The Gut–Liver Axis in MASLD: From Host–Microbiome Crosstalk to Precision Therapeutics. Microorganisms 2026, 14: 471. PMID: 41753757, PMCID: PMC12942669, DOI: 10.3390/microorganisms14020471.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGut-liver axisGut-liverHost-microbiome crosstalkMicrobiome-based interventionsSteatotic liver diseaseGut-derived productsIntestinal barrier integrityHost metabolismGut microbiotaMicrobial ecosystemTranslational landscapeHost microbiomeMetabolic dysbiosisPrecision therapeuticsDisease modifiersBarrier integrityEffective therapeutic optionPersonalized therapeutic strategiesExtrinsic factorsNon-invasive biomarkersTherapeutic strategiesTherapeutic optionsRisk stratificationHepatic insultImmune activationElovl6 inhibits colorectal cancer progression through stearic acid–mediated mitochondrial fusion and metabolic reprogramming
Bi Z, Chang X, Zhu S, Fu S, Zhang Y, Wang T, Wang F, Zhuang H, Hua Z. Elovl6 inhibits colorectal cancer progression through stearic acid–mediated mitochondrial fusion and metabolic reprogramming. Science Advances 2026, 12: eadz2892. PMID: 41686894, PMCID: PMC12904185, DOI: 10.1126/sciadv.adz2892.Peer-Reviewed Original ResearchConceptsMetabolic reprogrammingMitochondrial fusionPhospholipid biosynthesis pathwayColorectal cancerLipid metabolic reprogrammingIntestinal microbial homeostasisLipid metabolizing enzymesColorectal cancer progressionColon cancer tissuesBiosynthesis pathwayMicrobial homeostasisOpportunistic pathogenLow expression levelsTumor growth in vivoGrowth in vivoMolecular mechanismsCellular proliferation in vitroMetabolic enzymesColorectal cancer preventionELOVL6Protein 6Down-regulationProliferation in vitroUnfavorable patient prognosisCancer progression