Tingting Wang
Postdoctoral AssociateAbout
Research
Publications
2024
Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity
Zhang Z, Li P, Chen Y, Chen Y, Wang X, Shen S, Zhao Y, Zhu Y, Wang T. Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity. Cell Communication And Signaling 2024, 22: 210. PMID: 38566195, PMCID: PMC10986078, DOI: 10.1186/s12964-024-01581-2.Peer-Reviewed Original ResearchConceptsMitochondrial oxidative phosphorylationDisseminated candidiasisC. tropicalisMyeloid-derived suppressor cellsAntifungal immunityOxidative phosphorylationAcute kidney injuryMolecular mechanismsExpression of solute carrier family 7 memberExpression of mitochondrial proteinsInhibition of mitochondrial oxidative phosphorylationKidney injurySolute carrier family 7 memberSusceptible to ferroptosisRNA sequencing analysisCandida tropicalisQuantitative real-time PCRHost antifungal immunityMitochondrial proteinsC-type lectin receptorsIncreased susceptibility to acute kidney injuryProportion of myeloid-derived suppressor cellsCARD9Susceptibility to acute kidney injuryReal-time PCRAcatulides A-G, neuroprotective macrolides from Acaulium album H-JQSF
Tong Z, Wang T, Yang P, Sun J, Zhang C, Khan S, Wang X, Jiao R, Ge H, Zhuang W, Hu G, Tan R. Acatulides A-G, neuroprotective macrolides from Acaulium album H-JQSF. Chinese Chemical Letters 2024, 35: 108488. DOI: 10.1016/j.cclet.2023.108488.Peer-Reviewed Original ResearchIrpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088
Wang T, Tian J, Huang J, Yuan Y, Naman C, Wu S, Wang H, Lin W, Tong Z, Ding L, Wang W, He S. Irpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088. Journal Of Natural Products 2024, 87: 1203-1208. PMID: 38359398, DOI: 10.1021/acs.jnatprod.3c01078.Peer-Reviewed Original ResearchPestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145
Wang T, Feng Y, Huang J, Wu S, Hu K, Wu J, Naman C, Wang H, Lin W, He S. Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145. Journal Of Natural Products 2024, 87: 160-165. PMID: 38194474, DOI: 10.1021/acs.jnatprod.3c00892.Peer-Reviewed Original Research
2023
PANoptosis in cancer, the triangle of cell death
Cai H, Lv M, Wang T. PANoptosis in cancer, the triangle of cell death. Cancer Medicine 2023, 12: 22206-22223. PMID: 38069556, PMCID: PMC10757109, DOI: 10.1002/cam4.6803.Peer-Reviewed Original ResearchA novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
Al-Thani M, Goodwin-Trotman M, Bell S, Patel K, Fleming L, Vilain C, Abramowicz M, Allan S, Wang T, Cader M, Horsburgh K, Van Agtmael T, Sinha S, Markus H, Granata A. A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases. Stem Cell Reports 2023, 18: 2386-2399. PMID: 37977146, PMCID: PMC10724071, DOI: 10.1016/j.stemcr.2023.10.014.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseMatrix metalloproteinasesVessel diseaseCerebral small vessel diseaseKey pathogenic roleEndothelial cell tight junctionsHuman iPSC modelSVD pathologyCo-culture modelLeading causePathogenic roleCell phenotypic changesExtracellular matrixParacrine actionCell tight junctionsMMP activityTherapeutic opportunitiesECM abnormalitiesCell defectsEndothelial cellsMural cellsSmall vesselsTight junctionsIPSC modelsDiseaseA multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia
Sri S, Greenstein A, Granata A, Collcutt A, Jochems A, McColl B, Castro B, Webber C, Reyes C, Hall C, Lawrence C, Hawkes C, Pegasiou-Davies C, Gibson C, Crawford C, Smith C, Vivien D, McLean F, Wiseman F, Brezzo G, Lalli G, Pritchard H, Markus H, Bravo-Ferrer I, Taylor J, Leiper J, Berwick J, Gan J, Gallacher J, Moss J, Goense J, McMullan L, Work L, Evans L, Stringer M, Ashford M, Abulfadl M, Conlon N, Malhotra P, Bath P, Canter R, Brown R, Ince S, Anderle S, Young S, Quick S, Szymkowiak S, Hill S, Allan S, Wang T, Quinn T, Procter T, Farr T, Zhao X, Yang Z, Hainsworth A, Wardlaw J. A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia. Cerebral Circulation - Cognition And Behavior 2023, 5: 100189. PMID: 37941765, PMCID: PMC10628644, DOI: 10.1016/j.cccb.2023.100189.Peer-Reviewed Original ResearchVascular cognitive impairmentAlzheimer's diseaseAD brain pathologySmall vessel diseaseClinical featuresMixed pathologyMost dementiasVascular dementiaVessel diseaseVascular contributionsBrain pathologyCognitive impairmentDementiaPreclinical researchOlder peopleDiseasePathologyCommon typeDementia researchHuman pathologiesVCI modelPathogenesisEtiologyImpairmentLow expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis
Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y, Zhao S, Wang T. Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis. International Journal Of Biological Sciences 2023, 19: 4672-4688. PMID: 37781028, PMCID: PMC10535707, DOI: 10.7150/ijbs.81595.Peer-Reviewed Original ResearchConceptsReversible epigenetic modificationAbundant internal modificationPhosphoinositide-3-kinase regulatory subunit 1Glucosidase II alpha subunitRNA immunoprecipitation sequencingM6A reader proteinM6A-dependent mannerRegulatory subunit 1Reader proteinsYTH domainOvarian cancer progressionReader YTHDC1Chromatin immunoprecipitationImmunoprecipitation sequencingWestern blotEpigenetic modificationsGlycan biosynthesisBioinformatics analysisRNA sequencingRNA immunoprecipitationSignal transducerBiological roleGene expressionRegulatory mechanismsTranscription 3Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Zhang W, Zhao X, Qi X, Kimber S, Hooper N, Wang T. Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Frontiers In Cellular Neuroscience 2023, 17: 1195470. PMID: 37361999, PMCID: PMC10285224, DOI: 10.3389/fncel.2023.1195470.Peer-Reviewed Original ResearchBrain microvascular endothelial-like cellsTransendothelial electrical resistanceCerebral autosomal dominant arteriopathyAutosomal dominant arteriopathyCADASIL patientsNeurovascular interactionsMural cellsNeurovascular unitSubcortical infarctsBlood-brain barrier functionPluripotent stem cell modelsBarrier functionBrain MRI lesionsSmall vessel diseaseBrain barrier functionCortical projection neuronsStem cell modelWild-type astrocytesFuture therapeutic developmentNVU cell typesVascular mural cellsEarly disease pathologyInduced Pluripotent Stem Cell ModelRecurrent strokeCell typesEditorial: Fungal secondary metabolites as valuable chemical entities for medicines and agrochemicals
Wang W, Wang T. Editorial: Fungal secondary metabolites as valuable chemical entities for medicines and agrochemicals. Frontiers In Microbiology 2023, 14: 1150023. PMID: 36814564, PMCID: PMC9939815, DOI: 10.3389/fmicb.2023.1150023.Peer-Reviewed Original Research