Human Polymorphonuclear Leukocytes Generate and Degrade Endothelin-1 by Two Distinct Neutral Proteases
Sessa W, Kaw S, Zembowicz A, Änggård E, Hecker M, Vane J. Human Polymorphonuclear Leukocytes Generate and Degrade Endothelin-1 by Two Distinct Neutral Proteases. Journal Of Cardiovascular Pharmacology 1991, 17: s34-38. PMID: 1725374, DOI: 10.1097/00005344-199100177-00010.Peer-Reviewed Original ResearchConceptsET-1Big endothelinEndothelin-1Important pathophysiologic implicationsHuman polymorphonuclear leukocytesFMLP-activated PMNHuman big endothelinContractile factorsPMN infiltrationLeukocyte cathepsin GContractile activityPathophysiologic implicationsActivated PMNsPolymorphonuclear leukocytesNeutral proteaseDisease statesCell-free supernatantCathepsin GPMNPhosphoramidonMetabolismThe biosynthesis of endothelin-1 by human polymorphonuclear leukocytes
Sessa W, Kaw S, Hecker M, Vane J. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochemical And Biophysical Research Communications 1991, 174: 613-618. PMID: 1993057, DOI: 10.1016/0006-291x(91)91461-k.Peer-Reviewed Original Research