1987
Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers
Bowe C, Kocsis J, Targ E, Waxman S. Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers. Annals Of Neurology 1987, 22: 264-268. PMID: 2821876, DOI: 10.1002/ana.410220212.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAction PotentialsAminopyridinesAnimalsAxonsFemaleLysophosphatidylcholinesMotor ActivityMyelin SheathNerve Fibers, MyelinatedRatsSensationSpinal Nerve RootsConceptsSensory fibersClinical trialsAction potentialsPotassium channel blockadeDorsal root axonsCompound action potentialDorsal spinal rootsSingle action potentialMammalian motorIntrathecal injectionMultiple sclerosisSensory dysfunctionVentral rootsSpinal rootsNeuromuscular disordersSpecific fiber typesElectrophysiological responsesSingle stimulusPhysiological effectsTrialsFiber typesResponseParesthesiaSclerosisDysfunction
1983
Myelin protein metabolism in demyelination and remyelination in the sciatic nerve
Smith M, Kocsis J, Waxman S. Myelin protein metabolism in demyelination and remyelination in the sciatic nerve. Brain Research 1983, 270: 37-44. PMID: 6871715, DOI: 10.1016/0006-8993(83)90789-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsLysophosphatidylcholinesMaleMicroscopy, ElectronMyelin ProteinsMyelin SheathRatsSciatic NerveConceptsMyelin proteinsControl nervesLPC injectionSciatic nerveRight sciatic nerveSeries of ratsLeft nerveSchwann cellsNerveStructural myelin proteinsLPC treatmentFirst weekTime pointsAmino acid incorporationProtein metabolismLabeled amino acidsAcid incorporationMyelinDaysInjectionLysophosphatidylcholineDemyelinationRemyelinationProteinRats
1980
Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Electron-microscopic observations
Foster R, Kocsis J, Malenka R, Waxman S. Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Electron-microscopic observations. Journal Of The Neurological Sciences 1980, 48: 221-231. PMID: 7431040, DOI: 10.1016/0022-510x(80)90202-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain DiseasesCorpus CallosumDemyelinating DiseasesFemaleLysophosphatidylcholinesMicroscopy, ElectronRabbitsConceptsCorpus callosumLysophosphatidyl cholineFocal demyelinating lesionsCentral nervous systemDemyelinating lesionsLPC injectionDemyelinated axonsFocal demyelinationElectron microscopic examinationElectrophysiological studiesNervous systemElectrophysiological controlEarly signsCallosumAxonsDemyelinationInjectionElectron microscopic observationsRemyelinationPressure injectionLesions
1979
Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Light-microscopic observations
Waxman S, Kocsis J, Nitta K. Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Light-microscopic observations. Journal Of The Neurological Sciences 1979, 44: 45-53. PMID: 512691, DOI: 10.1016/0022-510x(79)90221-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus CallosumDemyelinating DiseasesDisease Models, AnimalFemaleLysophosphatidylcholinesRabbits