1991
Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve
Gardon T, Kocsis J, Waxman S. Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve. Muscle & Nerve 1991, 14: 640-646. PMID: 1922170, DOI: 10.1002/mus.880140707.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsAxonsElectric StimulationNerve RegenerationPotassium ChannelsRatsRats, Inbred StrainsSciatic NerveTetraethylammoniumTetraethylammonium CompoundsConceptsCompound action potentialRat sciatic nerveNerve crushRegenerated axonsSciatic nerveRegenerated nervesInward rectificationIntra-axonal recording techniquesAdult rat sciatic nerveTEA-sensitive potassium channelsPotassium channelsRegenerated rat sciatic nerveSucrose gap recordingsSciatic nerve crushPeripheral nerve axonsWhole nerve recordingsIntra-axonal recordingsVoltage-sensitive sodium channelsCrush injuryNormal nervesSensitive relaxationRepetitive stimulationAfterhyperpolarizationGap recordingsNerve recordings
1989
Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve
Gordon T, Kocsis J, Waxman S. Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve. Brain Research 1989, 502: 252-257. PMID: 2555026, DOI: 10.1016/0006-8993(89)90620-3.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsFemaleMembrane PotentialsNeural InhibitionOptic NerveRatsRats, Inbred StrainsTetraethylammonium CompoundsConceptsRat optic nerveOptic nerveEarly afterhyperpolarizationPharmacological sensitivityAction potentialsPeak latencyAction potential broadeningConstant current depolarizationSucrose gap chamberPotassium channel blockerLate afterhyperpolarizationChannel blockersRepetitive stimulationAfterhyperpolarizationNervePotassium conductanceSucrose gapTetraethylammoniumPotential broadeningCurrent depolarizationDepolarizationDurationApaminBlockersCharybdotoxin
1988
Evidence for the presence of two types of potassium channels in the rat optic nerve
Gordon T, Kocsis J, Waxman S. Evidence for the presence of two types of potassium channels in the rat optic nerve. Brain Research 1988, 447: 1-9. PMID: 2454699, DOI: 10.1016/0006-8993(88)90959-6.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAction PotentialsAminopyridinesAnimalsFemaleIon ChannelsNerve FibersOptic NervePotassiumRatsRats, Inbred StrainsTetraethylammoniumTetraethylammonium CompoundsConceptsRat optic nervePostspike positivityOptic nerveAction potential waveformPotassium channelsAction potential broadeningSingle-fiber recordingsRepetitive firing patternsAction potential repolarizationTEA-sensitive channelsDistinct potassium channelsPotential waveformPronounced afterhyperpolarizationFiber recordingsWhole nerveIntracellular hyperpolarizationGap recordingsRepetitive firingMyelinated axonsNerveAction potentialsPotential repolarizationAfterhyperpolarizationFiring patternsProlonged depolarization
1986
Mammalian optic nerve fibers display two pharmacologically distinct potassium channels
Kocsis J, Gordon T, Waxman S. Mammalian optic nerve fibers display two pharmacologically distinct potassium channels. Brain Research 1986, 383: 357-361. PMID: 2429732, DOI: 10.1016/0006-8993(86)90040-5.Peer-Reviewed Original ResearchConceptsOptic nerve fibersNerve fibersDistinct potassium channelsPotassium channelsRat optic nerve fibersNerve action potentialsAction potential characteristicsAction potential repolarizationTEA-sensitive channelsIntracellular hyperpolarizationAction potentialsPotential repolarizationSuction electrodeTetraethylammoniumPotential characteristicsRepolarizationPositivity
1985
Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation
Bowe C, Kocsis J, Waxman S. Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation. Proceedings Of The Royal Society B 1985, 224: 355-366. PMID: 2410932, DOI: 10.1098/rspb.1985.0037.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgingAnimalsGanglia, SpinalIon ChannelsMotor NeuronsNeurons, AfferentPotassiumRatsRats, Inbred StrainsSpinal Nerve RootsTetraethylammoniumTetraethylammonium CompoundsConceptsDorsal spinal rootsSensory fibersMammalian motorPotassium channelsSpinal rootsAction potentialsRoot fibersCompound action potentialSingle sensory fibresDorsal root fibersVentral root fibersClasses of axonsIndividual action potentialsPharmacological blockadeVentral rootsYoung rootsSensory axonsWhole nervePotassium conductanceAxon responsesCourse of maturationBlockadeAxonsRoots resultsDifferential sensitivity
1981
Action potential electrogenesis in mammalian central axons.
Kocsis J, Waxman S. Action potential electrogenesis in mammalian central axons. Advances In Neurology 1981, 31: 299-312. PMID: 6275668.Peer-Reviewed Original Research
1980
Absence of potassium conductance in central myelinated axons
Kocsis J, Waxman S. Absence of potassium conductance in central myelinated axons. Nature 1980, 287: 348-349. PMID: 7421994, DOI: 10.1038/287348a0.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAminopyridinesAnimalsElectric ConductivityNerve Fibers, MyelinatedPotassiumRatsSpinal CordTetraethylammonium CompoundsConceptsCentral myelinated axonsMyelinated axonsAction potentialsPotassium conductanceDorsal column axonsVoltage-clamp experimentsLate outward currentOutward currentsAxonsSodium ion permeabilityLate increaseDepolarization phasePotassium permeabilityAxonal membraneRepolarizationMyelinInitial increaseVoltage-dependent changesSodium inactivationDemyelinationPrevious studies