Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma.
Burger R, Waxman S, Gilbert H, Mehlman C, Allen R. Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma. Journal Of Clinical Investigation 1975, 56: 1262-1270. PMID: 171283, PMCID: PMC301989, DOI: 10.1172/jci108202.Peer-Reviewed Original ResearchConceptsVitamin B12-binding proteinsHepatocellular carcinomaR-type proteinNormal liver tissueCertain patientsAdolescent patientsPleural fluidHuman milkSame patientPatientsSialic acid contentTumor tissueImmunologic propertiesLiver tissueSurvival studiesMore sialic acidCarcinomaPlasma survivalHigh levelsSialic acidImmunoprecipitation assaysTissueSodium dodecyl sulfate-polyacrylamide gel electrophoresisDodecyl sulfate-polyacrylamide gel electrophoresisApparent molecular weight