2011
Essential roles for Pot1b in HSC self-renewal and survival
Wang Y, Shen MF, Chang S. Essential roles for Pot1b in HSC self-renewal and survival. Blood 2011, 118: 6068-6077. PMID: 21948176, PMCID: PMC3234665, DOI: 10.1182/blood-2011-06-361527.Peer-Reviewed Original ResearchAgingAnemia, AplasticAnimalsApoptosisBone Marrow CellsBone Marrow DiseasesBone Marrow Failure DisordersCell DifferentiationCell SurvivalCells, CulturedChromosomes, MammalianDNA DamageDNA-Binding ProteinsFemaleHematopoietic Stem CellsHemoglobinuria, ParoxysmalMaleMiceMice, Inbred ICRMice, Mutant StrainsMice, SCIDTelomereTumor Suppressor Protein p53
1999
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph K, Chang S, Lee H, Blasco M, Gottlieb G, Greider C, DePinho R. Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice. Cell 1999, 96: 701-712. PMID: 10089885, DOI: 10.1016/s0092-8674(00)80580-2.Peer-Reviewed Original ResearchConceptsOrganismal aging processTelomerase-null miceTelomerase-deficient miceTelomere functionOrganismal levelTelomere maintenanceCellular senescenceOverall fitnessPhysiological processesStress responseHematopoietic ablationGenetic instabilityTelomere lengthNull miceCritical roleLife spanWound healingAging processSpontaneous malignanciesSenescenceOrganismsFitnessPathophysiological symptomsRoleMice