2024
Nutrient-derived signals regulate eosinophil adaptation to the small intestine
Kutyavin V, Korn L, Medzhitov R. Nutrient-derived signals regulate eosinophil adaptation to the small intestine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2316446121. PMID: 38271336, PMCID: PMC10835075, DOI: 10.1073/pnas.2316446121.Peer-Reviewed Original ResearchConceptsRetinoic acid signalingCrypt-villus axisLocalization signalTissue-specific adaptationsAcid signalingAmino acidsFunctional significanceTranscriptional signatureHomeostatic conditionsSmall intestineTissue microenvironmentType 2 immunityPurified amino acidsSignalAccumulationEffector cellsBone marrowIL-5Eosinophil accumulationSubpopulationsIntestineEffectorAdaptationHigh-protein diet
2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological features
1998
Innate immune recognition and control of adaptive immune responses
Medzhitov R, Janeway C. Innate immune recognition and control of adaptive immune responses. Seminars In Immunology 1998, 10: 351-353. PMID: 9799709, DOI: 10.1006/smim.1998.0136.Peer-Reviewed Original Research