Ruben De Man
About
Research
Publications
2026
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchSingle-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
De Man R, McDonough J, Adams T, Nikola F, Rangel R, Anderson S, Manning E, Cala Garcia J, Moss B, Waich A, Poli F, Cardenas R, Coarfa C, Song Q, Bar-Joseph Z, Vanaudenaerde B, Wuyts W, Niklason L, Raredon M, Yan X, Rosas I, Kaminski N. Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy. Nature Communications 2026, 17: 2095. PMID: 41571679, PMCID: PMC12953888, DOI: 10.1038/s41467-026-68810-9.Peer-Reviewed Original Research
2025
Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks
Kurbanov D, Ahangari F, Adams T, De Man R, Tang J, Carlon M, Abu Hussein N, Cortesi E, Zapata M, De Sadelaar L, Wuyts W, Vanaudenaerde B, Kaminski N, McDonough J. Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l456-l462. PMID: 39970931, PMCID: PMC12169420, DOI: 10.1152/ajplung.00171.2024.Peer-Reviewed Original Research
2024
Predicting lung aging using scRNA-Seq data
Song Q, Singh A, McDonough J, Adams T, Vos R, De Man R, Myers G, Ceulemans L, Vanaudenaerde B, Wuyts W, Yan X, Schupp J, Hagood J, Kaminski N, Bar-Joseph Z. Predicting lung aging using scRNA-Seq data. PLOS Computational Biology 2024, 20: e1012632. PMID: 39700255, PMCID: PMC11741621, DOI: 10.1371/journal.pcbi.1012632.Peer-Reviewed Original Research
2019
Hybrid Neural Networks for Mortality Prediction from LDCT Images
Yan P, Guo H, Wang G, De Man R, Kalra MK. Hybrid Neural Networks for Mortality Prediction from LDCT Images. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2019, 00: 6243-6246. PMID: 31947269, DOI: 10.1109/embc.2019.8857180.Peer-Reviewed Original ResearchComparison of deep learning and human observer performance for lesion detection and characterization
De Man R, Gang G, Li X, Wang G. Comparison of deep learning and human observer performance for lesion detection and characterization. Proceedings Of SPIE--the International Society For Optical Engineering 2019, 11072: 110721f-110721f-5. DOI: 10.1117/12.2532331.Peer-Reviewed Original ResearchComparison of deep learning and human observer performance for detection and characterization of simulated lesions
De Man R, Gang GJ, Li X, Wang G. Comparison of deep learning and human observer performance for detection and characterization of simulated lesions. Journal Of Medical Imaging 2019, 6: 025503-025503. PMID: 31263738, PMCID: PMC6586983, DOI: 10.1117/1.jmi.6.2.025503.Peer-Reviewed Original Research
2018
Multifactorial Analysis of Mortality in Screening Detected Lung Cancer
Digumarthy SR, De Man R, Canellas R, Otrakji A, Wang G, Kalra MK. Multifactorial Analysis of Mortality in Screening Detected Lung Cancer. Journal Of Oncology 2018, 2018: 1296246. PMID: 29861726, PMCID: PMC5976935, DOI: 10.1155/2018/1296246.Peer-Reviewed Original Research
2016
Upper-Bound on Dose Reduction in CT Reconstruction for Nodule Detection
De Man R, Wang G, Kalra M, Otrakji A, Hsieh S, Pelc N. Upper-Bound on Dose Reduction in CT Reconstruction for Nodule Detection. IEEE Access 2016, 4: 4247-4253. DOI: 10.1109/access.2016.2592941.Peer-Reviewed Original Research