2001
Glutamate regulates actin-based motility in axonal filopodia
Chang S, De Camilli P. Glutamate regulates actin-based motility in axonal filopodia. Nature Neuroscience 2001, 4: 787-793. PMID: 11477424, DOI: 10.1038/90489.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBridged Bicyclo Compounds, HeterocyclicCalciumCalcium ChannelsCell DifferentiationCell MovementCells, CulturedCentral Nervous SystemGlutamic AcidGreen Fluorescent ProteinsGrowth ConesHippocampusImmunohistochemistryLuminescent ProteinsNeuronal PlasticityPseudopodiaRatsReceptors, AMPAReceptors, N-Methyl-D-AspartateTau ProteinsThiazolesThiazolidinesConceptsAdult nervous systemGlutamate receptorsNervous systemAxonal filopodiaAMPA/kainate glutamate receptorsKainate glutamate receptorsEffects of glutamateIonotropic glutamate receptorsCNQX treatmentSynaptic vesicle clustersAxonal arborsAxonal branchesDendritic spinesExtracellular Ca2Neurotransmitter glutamateSynaptic formationSynaptic plasticityInhibitory effectGlutamateReceptorsVesicle clustersNMDASynaptogenesisSpine
1997
Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15
Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler M, Salcini A, Di Fiore P, De Camilli P. Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15. FEBS Letters 1997, 419: 175-180. PMID: 9428629, DOI: 10.1016/s0014-5793(97)01451-8.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsCalcium-Binding ProteinsClathrinEndocytosisHumansImmunohistochemistryIntracellular Signaling Peptides and ProteinsMolecular Sequence DataNerve EndingsNerve Tissue ProteinsPhosphoproteinsPhosphoric Monoester HydrolasesRatsSequence AlignmentSynaptic TransmissionSynaptic VesiclesConceptsSynaptojanin 1Endocytic intermediatesClathrin-coated pitsCOOH-terminal regionEH domainSpecies threeEps15Multiplicity of interactionsPutative roleClathrinNerve terminalsEndocytosisIsoformsProteinPrevious dataMotifInositolIntermediatesBindingInteractionPhenylalanineLocalizationNew evidenceDomain
1990
Synapsins in the vertebrate retina: Absence from ribbon synapses and heterogeneous distribution among conventional synapses
Mandell J, Townes-Anderson E, Czernik A, Cameron R, Greengard P, De Camilli P. Synapsins in the vertebrate retina: Absence from ribbon synapses and heterogeneous distribution among conventional synapses. Neuron 1990, 5: 19-33. PMID: 2114884, DOI: 10.1016/0896-6273(90)90030-j.Peer-Reviewed Original ResearchConceptsConventional synapsesRibbon synapsesAmacrine cellsBipolar cellsIntrinsic membrane proteinsSynapsin IAdult rat retinaNerve terminal phosphoproteinVertebrate retinaMembrane proteinsNerve terminalsRat retinaVesicle clusteringSalamander retinaSynapse typesSynaptic vesiclesMolecular differencesRetinaRod cellsSynapsesCone cellsSynapsinCellsSynaptophysinPhosphoproteinAutoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome
Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome. New England Journal Of Medicine 1990, 322: 1555-1560. PMID: 2135382, DOI: 10.1056/nejm199005313222202.Peer-Reviewed Original ResearchConceptsStiff-man syndromeInsulin-dependent diabetes mellitusGABA-ergic neuronsGlutamic acid decarboxylaseGamma-aminobutyric acidDiabetes mellitusPancreatic beta cellsAutoimmune diseasesBeta cellsOrgan-specific autoimmune diseasesNeurotransmitter gamma-aminobutyric acidPresence of autoantibodiesGroup of patientsCentral nervous systemPrimary autoantigenUnknown pathogenesisRare disorderAutoantibodiesNervous systemSyndromeUseful markerMellitusAcid decarboxylaseStriking associationPatients
1989
Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor
Mignery G, Südhof T, Takei K, De Camilli P. Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor. Nature 1989, 342: 192-195. PMID: 2554146, DOI: 10.1038/342192a0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCalcium ChannelsCerebellumCloning, MolecularFluorescent Antibody TechniqueImmunohistochemistryInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIntracellular MembranesMiceMolecular Sequence DataPurkinje CellsReceptors, Cell SurfaceReceptors, CholinergicReceptors, Cytoplasmic and NuclearRyanodineRyanodine Receptor Calcium Release ChannelConceptsEndoplasmic reticulumCalcium channel proteinsIntracellular second messengerRelative molecular massIntracellular membranesSecond messengerIntracellular compartmentsMolecular massEfficacy of neurotransmissionPutative receptorDirect roleProteinCalcium releaseGrowth factorReticulumDendritic spinesTrisphosphateIntracellular storesPresynaptic terminalsInositolIntracellular calcium storesReceptorsCalcium storesRNA6Immunocytochemistry
1987
Synaptophysin immunoreactivity and small clear vesicles in neuroendocrine cells and related tumours
Buffa R, Rindi G, Sessa F, Gini A, Capella C, Jahn R, Navone F, De Camilli P, Solcia E. Synaptophysin immunoreactivity and small clear vesicles in neuroendocrine cells and related tumours. Molecular And Cellular Probes 1987, 1: 367-381. PMID: 3134611, DOI: 10.1016/0890-8508(87)90018-1.Peer-Reviewed Original ResearchConceptsSynaptophysin immunoreactivityNeuroendocrine cellsClear vesiclesGut endocrine tumorsHuman adrenal medullaThyroid medullary carcinomaSmall clear vesiclesNon-chromaffin paragangliomaParathyroid adenomaMedullary carcinomaNeuroendocrine carcinomaNeuroendocrine tumorsCarotid bodyEndocrine tumorsGastrointestinal mucosaLung carcinoidsNerve terminalsPituitary adenomasAdrenal medullaPituitary cellsTumorsEndocrine cellsImmunoreactivityEndocrine granulesGeneral marker