2001
Association of Na+-H+ Exchanger Isoform NHE3 and Dipeptidyl Peptidase IV in the Renal Proximal Tubule*
Girardi A, Degray B, Nagy T, Biemesderfer D, Aronson P. Association of Na+-H+ Exchanger Isoform NHE3 and Dipeptidyl Peptidase IV in the Renal Proximal Tubule*. Journal Of Biological Chemistry 2001, 276: 46671-46677. PMID: 11590171, DOI: 10.1074/jbc.m106897200.Peer-Reviewed Original ResearchConceptsApical membraneExchanger Isoform NHE3Dipeptidyl peptidase IVN-terminal sequencingProtein complexesDPPIV enzyme activityRenal microvillus membrane vesiclesMicrovillar fractionMembrane populationsMembrane vesiclesPeptidase IVWestern blot analysisMicrovillus membrane vesiclesNHE3 surface expressionBrush borderImmunoelectron microscopyRabbit renal brush borderBlot analysisProteinEnzyme activitySurface expressionMicrovillus membraneNHE3Different poolsImmunoaffinity chromatography
1991
High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles
Desir GV, Cragoe EJ, Aronson PS. High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles. Journal Of Biological Chemistry 1991, 266: 2267-2271. PMID: 1846621, DOI: 10.1016/s0021-9258(18)52238-9.Peer-Reviewed Original ResearchConceptsMembrane vesiclesMicrovillus membrane vesiclesRenal microvillus membrane vesiclesSimilar rank order potencyBinding sitesInternal sitesHigh-affinity inhibitorsMembrane localizationInternal binding siteAmiloride analoguesPlasma membraneRank order potencyHigh-affinity bindingAffinity inhibitorsHigh affinity-binding siteVesiclesBasolateral membrane vesiclesOrder potency
1986
Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.
Grassl SM, Aronson PS. Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Biological Chemistry 1986, 261: 8778-8783. PMID: 3013862, DOI: 10.1016/s0021-9258(19)84448-4.Peer-Reviewed Original Research
1985
Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
Guggino SE, Aronson PS. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes. Journal Of Clinical Investigation 1985, 76: 543-547. PMID: 4031062, PMCID: PMC423858, DOI: 10.1172/jci112004.Peer-Reviewed Original ResearchConceptsLow dosesParadoxical effectUrate transportProximal tubular cellsUrate accumulationRenal urate excretionCanine renal cortexUrate retentionInside-alkaline pH gradientUricosuric drugsUrate reabsorptionRenal cortexUrate excretionTubular cellsHigh dosesCotransport pathwayDosesSame transport systemPyrazinoateLuminal membraneUrate uptakeAnion exchange pathwayDrugsMicrovillus membrane vesicles
1984
Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles
Seifter JL, Knickelbein R, Aronson PS. Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles. American Journal Of Physiology 1984, 247: f753-f759. PMID: 6093589, DOI: 10.1152/ajprenal.1984.247.5.f753.Peer-Reviewed Original Research
1983
Urate transport via anion exchange in dog renal microvillus membrane vesicles
Kahn AM, Aronson PS. Urate transport via anion exchange in dog renal microvillus membrane vesicles. American Journal Of Physiology 1983, 244: f56-f63. PMID: 6849384, DOI: 10.1152/ajprenal.1983.244.1.f56.Peer-Reviewed Original ResearchConceptsDose-response curveP-aminohippurateUrate transportRenal microvillus membrane vesiclesUptake of PAHDog renal cortexMicrovillus membrane vesiclesAnion reabsorptionRenal cortexProximal tubulesTransport of urateUrateBrush border membrane vesiclesMembrane vesiclesUrate uptakePAH uptakeExternal ClPresent studyBorder membrane vesicles
1982
Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles
Aronson P, Nee J, Suhm M. Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles. Nature 1982, 299: 161-163. PMID: 7110335, DOI: 10.1038/299161a0.Peer-Reviewed Original ResearchDetermination of the coupling ratio for Na+-H+ exchange in renal microvillus membrane vesicles
Kinsella J, Aronson P. Determination of the coupling ratio for Na+-H+ exchange in renal microvillus membrane vesicles. Biochimica Et Biophysica Acta 1982, 689: 161-164. PMID: 7104347, DOI: 10.1016/0005-2736(82)90200-0.Peer-Reviewed Original Research
1981
Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles
Kinsella JL, Aronson PS. Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles. American Journal Of Physiology 1981, 241: f374-f379. PMID: 7315961, DOI: 10.1152/ajprenal.1981.241.4.f374.Peer-Reviewed Original ResearchUse of ionophores to study Na+ transport pathways in renal microvillus membrane vesicles.
Aronson PS, Kinsella JL. Use of ionophores to study Na+ transport pathways in renal microvillus membrane vesicles. The FASEB Journal 1981, 40: 2213-7. PMID: 6263713.Commentaries, Editorials and LettersConceptsMembrane vesiclesRenal microvillus membrane vesiclesMicrovillus membrane vesiclesUse of ionophoresPlasma membrane vesiclesTransport pathwaysMembrane potential
1979
Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin B
Aronson PS, Hayslett JP, Kashgarian M. Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin B. American Journal Of Physiology 1979, 236: f392-f397. PMID: 434214, DOI: 10.1152/ajprenal.1979.236.4.f392.Peer-Reviewed Original ResearchConceptsAmphotericin BGlucose reabsorptionProximal tubulesNecturus proximal tubuleGlucose uptakeTubular glucose reabsorptionStopped-flow microperfusionRenal cortexRabbit renal cortexTubular lumenReabsorptionLuminal membraneGlucoseMicrovillus membrane vesiclesTubulesUptakeAmphotericinMembrane vesicle preparationsMicroperfusion