Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells
O'Connor D, Schechner J, Adida C, Mesri M, Rothermel A, Li F, Nath A, Pober J, Altieri D. Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells. American Journal Of Pathology 2000, 156: 393-398. PMID: 10666367, PMCID: PMC1850029, DOI: 10.1016/s0002-9440(10)64742-6.Peer-Reviewed Original ResearchConceptsTumor necrosis factor alpha/cycloheximideControl of apoptosisEndothelial cellsSurvivin expressionQuiescent endothelial cellsEndothelial cell survivalGrowth factorApoptosis inhibitor survivinTwo-dimensional cultureCaspase-3 activityRecombinant expressionFibroblast growth factorBasic fibroblast growth factorCell survivalStrong inductionProtein survivinPathological angiogenesisProtective genesRNA expressionVascular tubesSurvivinExpressionVascular endothelial growth factorApoptosisCells