2012
Non-synaptic inhibition between grouped neurons in an olfactory circuit
Su CY, Menuz K, Reisert J, Carlson JR. Non-synaptic inhibition between grouped neurons in an olfactory circuit. Nature 2012, 492: 66-71. PMID: 23172146, PMCID: PMC3518700, DOI: 10.1038/nature11712.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila olfactory receptor neuronsMalaria mosquito AnophelesMosquito AnophelesMammalian taste budsSustained responseInsect controlLateral inhibitionBroad occurrenceChemosensory sensillaOlfactory behaviorTransient activationSensory organsMarked compartmentalizationOlfactory circuitFunctional impactReceptor neuronsReceptor cellsOlfactory informationInhibitionInsectsTaste budsNeuronsCompartmentalizationBuds
2010
Odorant reception in the malaria mosquito Anopheles gambiae
Carey AF, Wang G, Su CY, Zwiebel LJ, Carlson JR. Odorant reception in the malaria mosquito Anopheles gambiae. Nature 2010, 464: 66-71. PMID: 20130575, PMCID: PMC2833235, DOI: 10.1038/nature08834.Peer-Reviewed Original ResearchConceptsMosquito Anopheles gambiaeOdorant receptor repertoireAnopheles gambiaeMalaria mosquito Anopheles gambiaeOdorant receptionReceptor repertoireMolecular basisHost-seeking behaviorEcological needsMajor vectorHuman hostTransmission of malariaGambiaeUseful targetCentral roleReceptorsStrong responseRepertoireMalariaSaharan AfricaSpeciesOdorants
2009
Olfactory Perception: Receptors, Cells, and Circuits
Su CY, Menuz K, Carlson JR. Olfactory Perception: Receptors, Cells, and Circuits. Cell 2009, 139: 45-59. PMID: 19804753, PMCID: PMC2765334, DOI: 10.1016/j.cell.2009.09.015.Peer-Reviewed Original Research
2008
Translation of Sensory Input into Behavioral Output via an Olfactory System
Kreher SA, Mathew D, Kim J, Carlson JR. Translation of Sensory Input into Behavioral Output via an Olfactory System. Neuron 2008, 59: 110-124. PMID: 18614033, PMCID: PMC2496968, DOI: 10.1016/j.neuron.2008.06.010.Peer-Reviewed Original ResearchA Regulatory Code for Neuron-Specific Odor Receptor Expression
Ray A, van Naters W, Carlson JR. A Regulatory Code for Neuron-Specific Odor Receptor Expression. PLOS Biology 2008, 6: e125. PMID: 18846726, PMCID: PMC2430909, DOI: 10.1371/journal.pbio.0060125.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsORN classesAxon guidance genesOdor receptorsAmino acid sequenceMost olfactory receptor neuronsReceptor gene regulationDrosophila speciesPhylogenetic approachGene regulationGenome sequenceTranscription factorsIndividual olfactory receptor neuronsRegulatory elementsAcid sequenceChemosensory organsRegulatory codeGenetic analysisMaxillary palpsGenesLarge repertoireReceptor neuronsReceptor geneExpressionNeuron map
2007
Receptors and Neurons for Fly Odors in Drosophila
van Naters W, Carlson JR. Receptors and Neurons for Fly Odors in Drosophila. Current Biology 2007, 17: 606-612. PMID: 17363256, PMCID: PMC1876700, DOI: 10.1016/j.cub.2007.02.043.Peer-Reviewed Original ResearchConceptsCis-vaccenyl acetateOlfactory receptor neuronsTrichoid sensillaAnti-aphrodisiac pheromoneReceptor gene familyVirgin femalesVivo expression systemGene familyMate recognitionMating partnersDrosophila antennaExpression systemORN populationCellular basisReceptor neuronsYield responseSensillaMale extractsElectrophysiological analysisFood odorsReceptorsDrosophilaMajor typesPheromoneFemales
2005
The Molecular Basis of Odor Coding in the Drosophila Larva
Kreher SA, Kwon JY, Carlson JR. The Molecular Basis of Odor Coding in the Drosophila Larva. Neuron 2005, 46: 445-456. PMID: 15882644, DOI: 10.1016/j.neuron.2005.04.007.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila larvaeMolecular basisVivo expression systemDifferent olfactory systemsFamily of receptorsSingle olfactory receptor neuronsLarval brainSpecificity mapsLarval antennal lobeExpression systemMolecular mechanismsOdor codingOdor receptorsReceptor neuronsIndividual receptorsAntennal lobeLongstanding observationGenesOlfactory systemLarvaeBreadth of tuningSingle glomerulusReceptorsOdor information
1999
Odor Coding in a Model Olfactory Organ: TheDrosophila Maxillary Palp
de Bruyne M, Clyne P, Carlson J. Odor Coding in a Model Olfactory Organ: TheDrosophila Maxillary Palp. Journal Of Neuroscience 1999, 19: 4520-4532. PMID: 10341252, PMCID: PMC6782632, DOI: 10.1523/jneurosci.19-11-04520.1999.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsDrosophila melanogasterMaleModels, AnatomicOdorantsOlfactory PathwaysOlfactory Receptor NeuronsSense OrgansConceptsReceptor neuronsOlfactory organOlfactory receptor neuronsCross-adaptation experimentsExcitatory responsesNeuronal typesExtracellular recordingsParticular neuronsNeuronsFunctional classSensilla typesOdor responsesOdor codingOlfactory informationOdor deliveryOrgansMaxillary palpsSensory hairsFunctional organizationSingle sensillaResponseDeliveryOlfactory codeParticular odorTwo-neuronThe Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor
Clyne P, Certel S, de Bruyne M, Zaslavsky L, Johnson W, Carlson J. The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor. Neuron 1999, 22: 339-347. PMID: 10069339, DOI: 10.1016/s0896-6273(00)81094-6.Peer-Reviewed Original ResearchConceptsPOU domain transcription factorOlfactory neuronsTranscription factorsIndividual olfactory neuronsOdorant response profilesSubset of neuronsOlfactory receptor neuronsOdor specificityPhysiological analysisAcj6Neuronal identityOlfactory behaviorMolecular analysisReceptor neuronsNeuronsReceptor geneOlfactory codingGenesResponse profilesMutantsSpecificitySubsetA Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila
Clyne P, Warr C, Freeman M, Lessing D, Kim J, Carlson J. A Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila. Neuron 1999, 22: 327-338. PMID: 10069338, DOI: 10.1016/s0896-6273(00)81093-4.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsPOU domain transcription factorLarge multigene familyCandidate odorant receptorsTransmembrane domain proteinGenomic sequence databasesSubset of ORNsDomain proteinsMultigene familyAntennal developmentOdorant receptorsTranscription factorsSequence databasesInitiate expressionOlfactory organOdorant specificityNovel familyDifferent membersReceptor neuronsReceptor moleculesInsectsMutantsValuable modelGenesOlfactory system