2024
Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness
Sieu L, Singla S, Liu J, Zheng X, Sharafeldin A, Chandrasekaran G, Valcarce-Aspegren M, Niknahad A, Fu I, Doilicho N, Gummadavelli A, McCafferty C, Crouse R, Perrenoud Q, Picciotto M, Cardin J, Blumenfeld H. Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness. Cell Reports 2024, 43: 115012. PMID: 39643969, DOI: 10.1016/j.celrep.2024.115012.Peer-Reviewed Original ResearchCortical slow wavesFocal seizuresBehavioral responsesAuditory stimuliImpaired behavioral responsesFocal temporal lobe seizuresImpaired consciousnessMouse modelAwake mouse modelResponses to auditory stimuliBehavioral responses to auditory stimuliDecreased cortical arousalImpaired behaviorSlow wavesTemporal lobe seizuresCholinergic releaseModel of focal seizuresHigh-frequency activityCortical functionCortical arousalDepressed cortical functionSubcortical arousalArousalAcetylcholine releaseRat model
2015
Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology
Furman M, Zhan Q, McCafferty C, Lerner BA, Motelow JE, Meng J, Ma C, Buchanan GF, Witten IB, Deisseroth K, Cardin JA, Blumenfeld H. Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology. Epilepsia 2015, 56: e198-e202. PMID: 26530287, PMCID: PMC4679683, DOI: 10.1111/epi.13220.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresLimbic seizuresCortical functionBrainstem neuronsCortical dysfunctionFocal temporal lobe seizuresOptogenetic stimulationCortical slow-wave activityDepressed cortical functionSubcortical cholinergic neuronsTemporal lobe seizuresLoss of consciousnessPedunculopontine tegmental nucleusAnesthetized rat modelSlow wave activityCortical gamma activitySleep-like stateCholinergic neuronsFocal seizuresArousal networkCholinergic stimulationTegmental nucleusRat modelCortical physiologySeizures