2024
Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness
Sieu L, Singla S, Liu J, Zheng X, Sharafeldin A, Chandrasekaran G, Valcarce-Aspegren M, Niknahad A, Fu I, Doilicho N, Gummadavelli A, McCafferty C, Crouse R, Perrenoud Q, Picciotto M, Cardin J, Blumenfeld H. Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness. Cell Reports 2024, 43: 115012. PMID: 39643969, DOI: 10.1016/j.celrep.2024.115012.Peer-Reviewed Original ResearchCortical slow wavesFocal seizuresBehavioral responsesAuditory stimuliImpaired behavioral responsesFocal temporal lobe seizuresImpaired consciousnessMouse modelAwake mouse modelResponses to auditory stimuliBehavioral responses to auditory stimuliDecreased cortical arousalImpaired behaviorSlow wavesTemporal lobe seizuresCholinergic releaseModel of focal seizuresHigh-frequency activityCortical functionCortical arousalDepressed cortical functionSubcortical arousalArousalAcetylcholine releaseRat model
2015
Arousal and Locomotion Make Distinct Contributions to Cortical Activity Patterns and Visual Encoding
Vinck M, Batista-Brito R, Knoblich U, Cardin JA. Arousal and Locomotion Make Distinct Contributions to Cortical Activity Patterns and Visual Encoding. Neuron 2015, 86: 740-754. PMID: 25892300, PMCID: PMC4425590, DOI: 10.1016/j.neuron.2015.03.028.Peer-Reviewed Original ResearchConceptsSensory-evoked cortical activityCortical activity patternsLocomotion effectsMouse V1Spontaneous firingLocal field potentialsCortical circuitsCortical activityRunning wheelArea V1Visual responsesPatterns of activityPupil diameterPopulation activityField potentialsMotor feedbackArousalV1Activity patternsArousal levelTemporal patterningComplementary roleMiceActivity