2015
Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells
Messenger SW, Thomas D, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE. Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells. Cellular And Molecular Gastroenterology And Hepatology 2015, 1: 695-709. PMID: 26618189, PMCID: PMC4657148, DOI: 10.1016/j.jcmgh.2015.08.002.Peer-Reviewed Original ResearchEarly endosomesRecycling endosomesEndosomal traffickingLate endosomesDominant-negative Rab11a mutantCellular damage responseAssociated membrane proteinLysosome-Associated Membrane ProteinsPIKfyve inhibitionApical traffickingPIKfyve activityEndosomal systemCCK-8Damage responseMembrane proteinsPlasma membraneAcinar cellsPIKfyvePharmacological inhibitorsPancreatic acinar cellsTraffickingEndosomesZymogen activationAdenoviral overexpressionCellular death
2010
T1837 The Vacuolar ATPase Associates With CFTR in Apical Endocytic and Recycling Vesicles and Undergoes cAMP Regulated Trafficking in Intestinal Epithelial Cells
Collaco A, Jakab R, Gorelick F, Ameen N. T1837 The Vacuolar ATPase Associates With CFTR in Apical Endocytic and Recycling Vesicles and Undergoes cAMP Regulated Trafficking in Intestinal Epithelial Cells. Gastroenterology 2010, 138: s-589. DOI: 10.1016/s0016-5085(10)62715-1.Peer-Reviewed Original Research
2006
Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 1936-1940. PMID: 16449385, PMCID: PMC1413666, DOI: 10.1073/pnas.0510710103.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkOverexpression of PLD1Mutant neuronsPhospholipase D1Beta-amyloid precursor proteinIntracellular traffickingPS1-deficient cellsPLD enzymatic activityTherapeutic targetNeuronal functionPS1 mutationsOverexpression of WTBetaAPPPrecursor proteinMutant cellsSubcellular localizationNeurite outgrowthPLD1 activitySurface deliveryNeuronsOutgrowth capacityCellsTraffickingEnzymatic activityOverexpression