2024
3046 – FUNCTIONAL CHARACTERIZATION OF RBM15-MKL1 FUSION PROTEIN IN AMKL TUMORIGENESIS
Chen M, Mayday M, Espinosa A, Zhang M, Zhang P, Wang L, Rahman N, Krause D. 3046 – FUNCTIONAL CHARACTERIZATION OF RBM15-MKL1 FUSION PROTEIN IN AMKL TUMORIGENESIS. Experimental Hematology 2024, 137: 104368. DOI: 10.1016/j.exphem.2024.104368.Peer-Reviewed Original ResearchChromatin associationRBM15-MKL1TPA-induced megakaryocytic differentiationHuman erythroleukemiaAcute megakaryoblastic leukemiaAssociated with chromatinTranscriptional regulatory functionRNA-binding proteinsTranscriptional co-activatorM6A RNA modificationShRNA-mediated knock-downHuman erythroleukemia cellsChromatin regionsRNA modificationsTranscriptional regulationMolecular functionsAberrant transcriptsFusion proteinGO analysisMKL1Knock-downBinding proteinRegulatory functionsFusion geneDifferentiation block
2021
MRTFA: A critical protein in normal and malignant hematopoiesis and beyond
Reed F, Larsuel ST, Mayday MY, Scanlon V, Krause DS. MRTFA: A critical protein in normal and malignant hematopoiesis and beyond. Journal Of Biological Chemistry 2021, 296: 100543. PMID: 33722605, PMCID: PMC8079280, DOI: 10.1016/j.jbc.2021.100543.Peer-Reviewed Original ResearchConceptsMalignant hematopoiesisActin cytoskeleton dynamicsCritical cellular functionsResponse factorSerum response factorTranscription factor ACellular rolesImmediate early genesProtein partnersTranscriptional regulationCytoskeleton dynamicsCellular functionsTranscriptional targetsTranscription factorsCytoskeletal proteinsCritical proteinsMRTFAEarly genesCell typesChromosomal translocationsHematopoietic cellsCell growthFactor AHematopoiesisMuscle cells
2000
Regulation of CD34 transcription by Sp1 requires sites upstream and downstream of the transcription start site
Taranenko N, Krause D. Regulation of CD34 transcription by Sp1 requires sites upstream and downstream of the transcription start site. Experimental Hematology 2000, 28: 974-984. PMID: 10989198, DOI: 10.1016/s0301-472x(00)00492-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Antigens, NuclearBinding SitesDNADNA HelicasesDNA MethylationDNA ProbesDNA-Binding ProteinsGene Expression RegulationGuanineKu AutoantigenMiceNuclear ProteinsPromoter Regions, GeneticSp1 Transcription FactorTranscription FactorsTranscription, GeneticTransfectionTumor Cells, CulturedUntranslated RegionsConceptsTranscription start sitePromoter activityCD34 promoterStart siteDrosophila S2 cellsHematopoietic cellsTranscription factor bindsDNA binding sitesElectromobility shift assaysSequence-specific mannerS2 cellsTranscriptional regulationMolecular regulationMethylation interferenceDeletion analysisEarly hematopoiesisNuclear proteinsRegulatory regionsFactor bindsShift assaysGene expressionUntranslated regionHematopoietic stemSp1CD34 transcription
1997
Gotta find GATA a friend
Krause D, Perkins A. Gotta find GATA a friend. Nature Medicine 1997, 3: 960-961. PMID: 9288719, DOI: 10.1038/nm0997-960.Commentaries, Editorials and Letters