2019
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitors
2011
Activation of autophagy in mesenchymal stem cells provides tumor stromal support
Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR. Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis 2011, 32: 964-972. PMID: 21317300, PMCID: PMC3128555, DOI: 10.1093/carcin/bgr029.Peer-Reviewed Original ResearchConceptsSD-MSCsStromal cellsMesenchymal stem cellsMultipotential mesenchymal stem cellsMCF-7 tumor growthBreast cancer cell proliferationStem cellsVivo tumor xenograftsMCF-7 breast cancer cellsCancer cell proliferationSolid tumor survivalBreast cancer cellsBeclin-1 stainingActivation of autophagyAnti-apoptotic factorsTime-dependent increaseUpregulation of autophagySolid tumor microenvironmentBreast cancerImmunodeficient miceTumor xenograftsSolid tumorsTumor growthParacrine factorsSurvival mechanism
2009
Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells
Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells. Hepatology 2009, 51: 963-973. PMID: 20044808, PMCID: PMC2840188, DOI: 10.1002/hep.23389.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsHepatocyte growth factorMSC chemotaxisCellular injuryMesenchymal stem cellsAdenosine concentrationRegulation of HGFInhibition of HGFEffects of adenosineSite of injuryBone marrow-derived mesenchymal stem cellsHepatocyte-specific genesHigh adenosine concentrationsHuman marrow-derived mesenchymal stem cellsAdenosine monophosphateBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsConcentration of adenosineLiver injuryCytosolic calcium signalingStress fiber formationA2A receptorsHepatocyte-like cellsCyclic adenosine monophosphate
2008
Influence of Culture Medium on Smooth Muscle Cell Differentiation from Human Bone Marrow–Derived Mesenchymal Stem Cells
Gong Z, Calkins G, Cheng EC, Krause D, Niklason LE. Influence of Culture Medium on Smooth Muscle Cell Differentiation from Human Bone Marrow–Derived Mesenchymal Stem Cells. Tissue Engineering Part A 2008, 15: 319-330. PMID: 19115826, PMCID: PMC2716410, DOI: 10.1089/ten.tea.2008.0161.Peer-Reviewed Original Research
2005
Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005, 7: 393-395. PMID: 16236628, DOI: 10.1080/14653240500319234.Peer-Reviewed Original Research
2004
Plasticity of Bone Marrow–Derived Stem Cells
Grove JE, Bruscia E, Krause DS. Plasticity of Bone Marrow–Derived Stem Cells. Stem Cells 2004, 22: 487-500. PMID: 15277695, DOI: 10.1634/stemcells.22-4-487.Peer-Reviewed Original ResearchConceptsBone marrow stem cellsHematopoietic stem cellsStem cellsCell plasticityMesenchymal stem cellsStem cell plasticityGene expression profilesAdult stem cellsAdult bone marrow cellsMature lineagesAdult bone marrow stem cellsTissue of originExpression profilesMature cellsMarrow stem cellsBone marrow cellsNonhematopoietic tissuesMature phenotypePlasticityMarrow cellsCellsLineagesBone marrowPhenotypeTissue
2003
Plasticity of marrow-derived stem cells
Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003, 102: 3483-3493. PMID: 12893756, DOI: 10.1182/blood-2003-05-1664.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsStem cellsAdult stem cell plasticityMesenchymal stem cellsStem cell plasticityBone marrowMature blood cellsEndothelial cell progenitorsAdult bone marrowBone marrow subpopulationsMultiple mesenchymal tissuesCell plasticityMarrow-derived stem cellsCell progenitorsMarrow subpopulationsMultiple tissuesMature cellsConditions differentiationNeural cellsDifferentiationEpithelial cellsNonhematopoietic cellsTissue injuryGastrointestinal tractSkeletal muscleCotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice
Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, Krause DS. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Experimental Hematology 2003, 31: 413-420. PMID: 12763140, DOI: 10.1016/s0301-472x(03)00042-0.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsNOD/SCID miceMesenchymal stem cellsMSC cotransplantationTransplant recipientsSCID miceCotransplantation of MSCsHematopoietic stem cellsHuman peripheral blood stem cellsStem cellsAllogeneic transplant recipientsTransplantation of CD34Autologous transplant recipientsHuman mesenchymal stem cellsBlood stem cellsHuman cell engraftmentMarrow-derived stromal cellsBone marrow cellsPlatelet engraftmentHuman bone marrow cellsHuman hematopoietic stem cellsCotransplantationBone marrowMegakaryocytic engraftmentB lymphocytes