1993
Alteration of rat liver endoplasmic reticulum Ca2+-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator
Bennett A, Williams G. Alteration of rat liver endoplasmic reticulum Ca2+-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator. Biochemical Pharmacology 1993, 45: 2093-2098. PMID: 8512590, DOI: 10.1016/0006-2952(93)90021-n.Peer-Reviewed Original ResearchStudies on the Effects of Peroxisome Proliferators as Novel Ca2+ Mobilizing Agents Using Indo-1-Loaded Hepatocytes
Bennett A, Flint O, Williams G. Studies on the Effects of Peroxisome Proliferators as Novel Ca2+ Mobilizing Agents Using Indo-1-Loaded Hepatocytes. 1993, 143-151. DOI: 10.1007/978-1-4615-2828-9_17.Peer-Reviewed Original ResearchFatty acid metabolismNon-genotoxic hepatocarcinogensHypolipidemic drugsRodent hepatocarcinogensPeroxisome proliferatorHepatocyte proliferationHepatocellular organellesOxidative stressAcid metabolismDefinitive evidenceCarcinogenicityMobilizing agentHepatocarcinogensImportant roleHepatocytesProliferationAgentsPPAProliferatorPeroxisomes
1992
Reduction of rat liver endoplasmic reticulum Ca2+-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator
Bennett A, Williams G. Reduction of rat liver endoplasmic reticulum Ca2+-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator. Biochemical Pharmacology 1992, 43: 595-605. PMID: 1531754, DOI: 10.1016/0006-2952(92)90583-5.Peer-Reviewed Original ResearchConceptsATPase protein contentFree intracellular calcium concentrationLiver endoplasmic reticulumLiver microsomal Ca2Control levelsSingle oral doseMale F344 ratsIntracellular calcium concentrationEffect of ciprofibrateDose-dependent inhibitionControls 24 hrConcentration-dependent inhibitionEndoplasmic reticulum Ca2ATPase activityOral doseF344 ratsIntracellular calciumExtracellular calciumMicrosomal Ca2Peroxisome proliferatorTransient decreaseHepatic endoplasmic reticulumFunctional inhibitionMitogenic responseRats