2014
Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood
Levy AD, Omar MH, Koleske AJ. Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood. Frontiers In Neuroanatomy 2014, 8: 116. PMID: 25368556, PMCID: PMC4202714, DOI: 10.3389/fnana.2014.00116.Peer-Reviewed Original ResearchDendritic spinesMost excitatory synapsesCentral nervous systemLate-onset diseaseBrain extracellular matrixExcitatory synapsesExtracellular matrixSynapse stabilityOnset diseaseNervous systemSpine stabilityAlzheimer's diseaseSynapse formationAdult spineSynapse structureAdult animalsSpineDiseaseNormal functionSpine structureCircuit functionCritical regulatorAdulthoodMeshwork of proteinsECM receptors
2010
Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation
de Arce K, Varela-Nallar L, Farias O, Cifuentes A, Bull P, Couch BA, Koleske AJ, Inestrosa NC, Alvarez AR. Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation. Journal Of Neuroscience 2010, 30: 3728-3738. PMID: 20220006, PMCID: PMC2872795, DOI: 10.1523/jneurosci.2024-09.2010.Peer-Reviewed Original ResearchConceptsPSD-95Protein postsynaptic density protein 95Postsynaptic density protein 95PSD-95 clusteringHippocampal neuron culturesFirst postnatal weekC-AblC-Abl levelsPresynaptic markersTyrosine phosphorylationRat hippocampusPostnatal weekPostsynaptic sitesSynaptic clusteringNeuron culturesSynaptic functionC-Abl kinase activityReduced synapsesSynapse formationPostsynaptic compartmentsBrain synapsesGenetic inhibitionSynapsesTyrosine kinaseC-Abl tyrosine kinase