Henry Rinder, MD
Cards
Appointments
Titles
Vice Chair for Clinical Affairs, Laboratory Medicine; Associate Director, Yale Pathology Residency Program; Director, Clinical Hematology Laboratory
Contact Info
Laboratory Medicine
PO Box 208035
New Haven, CT 06520-8035
United States
Appointments
Titles
Vice Chair for Clinical Affairs, Laboratory Medicine; Associate Director, Yale Pathology Residency Program; Director, Clinical Hematology Laboratory
Contact Info
Laboratory Medicine
PO Box 208035
New Haven, CT 06520-8035
United States
Appointments
Titles
Vice Chair for Clinical Affairs, Laboratory Medicine; Associate Director, Yale Pathology Residency Program; Director, Clinical Hematology Laboratory
Contact Info
Laboratory Medicine
PO Box 208035
New Haven, CT 06520-8035
United States
About
Titles
Professor of Laboratory Medicine and of Medicine (Hematology)
Vice Chair for Clinical Affairs, Laboratory Medicine; Associate Director, Yale Pathology Residency Program; Director, Clinical Hematology LaboratoryBiography
My academic background is in hematology. After training in internal medicine and hematology, I went on to post-doctoral work in clinical pathology to bolster our clinical and research activities.
Our laboratory research focuses on cell-based diagnostics relevant to the basic biology of hemostasis and inflammation. We have evaluated the role of thrombin and complement in platelet dysfunction following extracorporeal circulation, studies of metabolic changes during platelet storage, hypercoagulability in drug abuse, and platelet function under the control of growth factors.
We also seek to understand platelet kinetics in a variety of disorders using the non-invasive peripheral blood assay for reticulated platelets. Our collaborative focus on research additionally includes: murine disease models of platelet activation and kinetics; cell-based vascular risk associated with CPB; platelet physiology; and neutrophil markers for early recognition of sepsis.
These rewarding areas of investigation have seamlessly led to clinical investigation and educative endeavors, including becoming an author on the 4th and 5th editions of Hillman's Hematology in Clinical Practice (McGraw-Hill) and serving currently on the Board of Directors of the American Society for Clinical Pathology (ASCP) and as the chair of the ASCP Commission on Continuing Professional Development.
Appointments
Laboratory Medicine
ProfessorPrimary
Other Departments & Organizations
- Apheresis
- Clinical Hematology Laboratory
- General Hematology
- Laboratory Medicine
- Laboratory Medicine - Education
- Training in Lab Med and Pathology
- Yale Medicine
- Yale Ventures
Education & Training
- Fellow
- Yale University School of Medicine (1992)
- Fellow
- Yale University School of Medicine (1990)
- Chief Resident
- Maine Medical Center (1988)
- Resident
- Maine Medical Center (1987)
- MD
- University of Vermont (1984)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0001-7271-7447
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Brian Richard Smith, MD
Alexa Siddon, MD
Alfred Lee, MD, PhD
Ayesha Butt, MBBS
Cristina A. Figueroa Villalba, MD
John Hwa, MD, PhD, FRACP
Blood Platelets
Cardiopulmonary Bypass
Blood Transfusion
Inflammation
Publications
2024
Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review
Jacobs J, Sharma D, Stephens L, Villalba C, Rinder H, Woo J, Wheeler A, Gerberi D, Goel R, Tormey C, Booth G, Bloch E, Adkins B. Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review. British Journal Of Haematology 2024, 204: 1500-1506. PMID: 38291731, DOI: 10.1111/bjh.19313.Peer-Reviewed Original ResearchAltmetricConceptsRisk of thrombosisHemoglobin C traitHemoglobin C diseaseVenous thromboembolismC diseaseIncreased risk of thrombosisProspective cohort studyFactor to thrombosisAssessment of patientsCohort studySystematic reviewInclusion criteriaPregnant individualsThrombotic riskCase seriesCase reportVTE riskChronic haemolysisSystematic literature reviewArterial thrombosisThrombosis riskHigh blood viscosityIncreased riskThrombosisC trait
2023
Heidenhain variant of Creutzfeldt-Jakob disease masquerading as neuromyelitis optica spectrum disorder: recognizing when apheresis is not the answer
Burke O, Jacobs J, Tormey C, Rinder H, Villalba C, Lee E, Campos J, Abels E, Yurtsever N. Heidenhain variant of Creutzfeldt-Jakob disease masquerading as neuromyelitis optica spectrum disorder: recognizing when apheresis is not the answer. Lab Medicine 2023, 55: 520-523. PMID: 38142129, DOI: 10.1093/labmed/lmad107.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderCreutzfeld-Jakob diseaseOptica spectrum disorderHeidenhain variantBilateral vision lossTherapeutic plasma exchangeReal-time quaking-induced conversionCreutzfeldt-Jakob diseaseImmunosuppressive therapyVisual disturbancesPlasma exchangeNeurocognitive symptomsTreatment modalitiesVision lossHospice careSpectrum disorderRare formPreliminary diagnosisDiseaseDiagnosisDisordersEarly stagesPatientsApheresisTherapyComprehensive Characterization of Coagulation Parameters in Venous Malformations
Restrepo V, Pine A, Butt A, Chang E, Bar N, Baluha A, Brooks A, Chirico G, Curran J, Dumont A, Obura-Wilkes P, Rinder H, Tormey C, Nassiri N, Lee A, Prozora S. Comprehensive Characterization of Coagulation Parameters in Venous Malformations. Blood 2023, 142: 27. DOI: 10.1182/blood-2023-190609.Peer-Reviewed Original ResearchConceptsHigher thrombin-antithrombin complexesNormal D-dimerThrombin-antithrombin complexPlasminogen activator inhibitor-1Localized intravascular coagulopathyInternational normalized ratioD-dimerVenous malformationsCoagulation parametersPartial thromboplastin timeCoagulation testsFactor VIIIVWF activityChart reviewMost patientsHematology clinicProthrombin timeTissue involvementVWF antigenVon Willebrand factor antigenHigher TAT levelsMultiple coagulation parametersBaseline patient characteristicsRetrospective chart reviewCoagulation test resultsMultimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders
Gu S, Gallagher P, Butt A, Gu V, Lezon-Geyda K, Schulz V, Prozora S, Lee A, Neparidze N, Bar N, Martin K, Cornell J, Chirico G, Chakraborty R, Rinder H, Hwa J, Bona R. Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders. Blood 2023, 142: 1197. DOI: 10.1182/blood-2023-177946.Peer-Reviewed Original ResearchConceptsBleeding tendencyBleeding disorderPlatelet markersPlatelet aggregometryMass cytometryPlatelet functionPlatelet disordersSingle-center prospective studyLow-risk groupAbnormal bleeding tendencyQualitative platelet disordersLarge patient cohortQuantitative platelet disordersCommon underlying causeGenetic variantsMultimodality evaluationTotal patientsRisk stratificationLaboratory suspicionPlatelet dysfunctionProspective studyPatient cohortUnivariate analysisPlatelet volumeRisk groupsBotulism mimicking Guillain‐Barre syndrome: The question of plasma exchange in an unusual case of acute paralysis
Campos J, Abels E, Rinder H, Tormey C, Jacobs J. Botulism mimicking Guillain‐Barre syndrome: The question of plasma exchange in an unusual case of acute paralysis. Journal Of Clinical Apheresis 2023, 38: 760-763. PMID: 37519071, DOI: 10.1002/jca.22081.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGuillain-Barré syndromeAcute flaccid paralysisFlaccid paralysisPlasma exchangeImmune-mediated polyradiculoneuropathyIntravenous immune globulinCranial nerve palsyGuillain-Barre syndromeCerebrospinal fluid analysisAppropriate therapeutic modalityCases of botulismAlbuminocytological dissociationNerve palsyRespiratory failureEmpiric administrationImmune globulinLaboratory featuresPrompt diagnosisIngestion/inhalationPoor outcomeAcute paralysisBotulinum toxinCommon causeTherapeutic modalitiesUnusual caseOptimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms
Puzo C, Tormey C, Rinder H, Siddon A. Optimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms. Transplantation And Cellular Therapy 2023, 29: 459.e1-459.e4. PMID: 37062510, DOI: 10.1016/j.jtct.2023.04.005.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAllogeneic stem cell transplantationStem cell transplantationDonor chimerismCell transplantationNGS testingPost allogeneic stem cell transplantationMeasurable residual diseaseNext-generation sequencingAcute myeloid leukemiaConditioning regimenRelated donorsMyelodysplastic syndromeResidual diseaseValidation cohortMyeloid leukemiaMyeloid neoplasmsNGS panelLogistic regressionPatientsChimerismSignificant predictorsCharacteristic curveTransplantationRegimenConservative thresholdQuantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants
Khan W, Tormey C, Rinder H, Siddon A. Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants. American Journal Of Clinical Pathology 2023, 159: 417-419. PMID: 36940149, DOI: 10.1093/ajcp/aqac183.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and Concepts
2022
Platelet production and kinetics
Binns T, Tormey C, Rinder H. Platelet production and kinetics. 2022, 158-167. DOI: 10.1002/9781119719809.ch15.ChaptersConceptsComplex biological processesPlatelet productionEpigenetic effectorsRegulatory RNAsMegakaryocyte differentiationPlatelet biogenesisAnucleate cellsGenetic regulationMatrix metalloproteinase proteinsNormal platelet productionMammalian physiologyTranscription factorsProplatelet processesSinusoidal blood vesselsBiological processesMature megakaryocytesMegakaryopoiesisMetalloproteinase proteinsMegakaryocytesHuman physiologyNew insightsEndothelial cellsTurnover rateNormal hemostasisPhysiologyA guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsVascular smooth muscle cellsPlatelet functional assaysCoronavirus disease 2019Smooth muscle cellsImmune cellsImmune regulationVascular remodelingDisease 2019Pathophysiological processesTranslational relevancePatient diagnosisFlow cytometryMuscle cellsPlatelet biologyFunctional assaysPlatelet investigationsHomeostatic processesPlateletsPhenotypic heterogeneityFunctional stateClinical scienceCellsAdditional roleThrombosisSuch diverse functions
2021
Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient
Jacobs JW, Gisriel SD, Iyer K, Rinder HM. Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient. Journal Of Thrombosis And Thrombolysis 2021, 53: 945-949. PMID: 34697688, PMCID: PMC8544916, DOI: 10.1007/s11239-021-02591-4.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPartial thromboplastin timeLupus anticoagulantFVIII inhibitorsAsymptomatic patientsFactor VIIIComprehensive hematologic evaluationLife-threatening hemorrhageTypical laboratory findingsDistinctive clinical presentationFactor VIII inhibitorsRisk of thrombosisSigns of hemorrhageSevere bleeding diathesisCoagulation factor VIIIImmunosuppressive therapyClinical presentationClinical symptomsPathologic antibodiesVIII inhibitorsLaboratory findingsHematologic evaluationUnique presentationBleeding diathesisThromboplastin timeAutoantibodies
Academic Achievements and Community Involvement
honor Past President
International AwardAcademy of Clinical Laboratory Physicians & ScientistsDetails05/29/2016United Stateshonor Michele D. Raible Lecturer
International AwardAmerican Society for Clinical PathologyDetails09/30/2015United Stateshonor 2013 President's Award
International AwardAmerican Society for Clinical PathologyDetails09/30/2013United States
Clinical Care
Overview
Henry Rinder, MD, is a hematologist, helping bolster research and clinical care surrounding various blood disorders, including bleeding and clotting diseases, anemias, and blood complications from other diseases.
Dr. Rinder's research focuses on cell-based diagnostics and basic biology principles involving inflammation and hemostasis—the body's reaction to an injury; this reaction stops the bleeding and allows the body to begin healing.
Through his clinical and research work, Dr. Rinder has established himself as an authority in hematology, including becoming an author on the 4th and 5th editions of Hillman's Hematology in Clinical Practice (McGraw-Hill).
Dr. Rinder is a professor of laboratory medicine and internal medicine (hematology) at Yale School of Medicine.
Clinical Specialties
Board Certifications
Clinical Pathology
- Certification Organization
- AB of Pathology
- Latest Certification Date
- 2014
- Original Certification Date
- 1994
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1987
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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News
- February 06, 2024
The FDA’s Proposed Ruling on Lab Tests Could Have Unintended Consequences
- August 11, 2022
Discoveries & Impact (August 2022)
- May 11, 2022
Andrea Barbieri, MD, to Succeed Diane Kowalski, MD, MMSc, as Director of Pathology Residency Training Program
- December 16, 2020
Discoveries & Impact (December 2020)
Get In Touch
Contacts
Laboratory Medicine
PO Box 208035
New Haven, CT 06520-8035
United States
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.